p-Toluenesulfonyl Chloride CAS 98-59-9
| CAS No. | 98-59-9 |
| Molecular Formula | C7H7ClO2S |
| Molecular Weight | 190.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
p-Toluenesulfonyl Chloride (CAS 98-59-9) is a high-purity analytical reference standard with the molecular formula C7H7ClO2S and a molecular weight of 190.65 g/mol.
The molecular framework of p-Toluenesulfonyl Chloride (C7H7ClO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), p-Toluenesulfonyl Chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7ClO2S |
| Molecular Weight | 190.65 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related p Standards
- o-Toluenesulfonyl Chloride (contains ca. 23% isomer) (CAS 133-59-5)
- p-Toluenesulfonyl Hydrazide (CAS 1576-35-8)
- m-toluenesulfonyl chloride (CAS 1899-93-0)
- p-Toluenesulfonyl isocyanate (CAS 4083-64-1)
- 4-Toluenesulfonyl cyanide (CAS 19158-51-1)
- 455-16-3 4-Toluenesulfonyl fluoride Benzenesulfonyl fluoride, 4-methyl- 4-Methylbenzenesulfonyl fluoride p-Toluenesulfonyl fluoride p-Toluenesulphonyl fluoride 4-11-00-00375 (Beilstein Handbook Reference) BRN 2208423 EINECS 207-238-6 p-Methylbenzenesulfonyl fluoride p-Methylphenylsulfonyl fluoride NSC 2749 Phenylmethylsulfonyl fluoride Toluene-4-sulfonyl fluoride Toluene-p-sulphonyl fluoride 4-Tolylsulfonyl fluoride Tosyl fluoride (CAS 455-16-3)
- 1-(p-Toluenesulfonyl)aziridine 1-(p-Toluenesulfonyl)ethylenimine 1-(p-Tolylsulfonyl)aziridine 1-Tosylaziridine 1-[(4-Methylphenyl)sulfonyl]aziridine 3634-89-7 N-(p-Toluenesulfonyl)aziridine N-(p-Tolylsulfonyl)aziridine N-Tosylaziridine N-[(4-Methylphenyl)sulfonyl]aziridine N-p-Tosylaziridine (CAS 3634-89-7)
- 1-(P-Toluenesulfonyl)pyrrole-2-aldehyde (CAS 102619-05-6)
Recommended Standards
- N-(Chloroacetyl)2-amino-4-methylthiazol (CAS 50772-53-7)
- Famotidine Impurity 27 (CAS 1378820-83-7)
- N-(5-Chloro-4-methylthiazol-2-yl)acetamide (CAS 21478-92-2)
- Famotidine Impurity 39 (CAS CATO-C4X-139239)
- 1-{[3-Chloro-4-(trifluoromethoxy)phenyl]methyl}-1,4-diazepane (CAS 1240581-70-7)
- (2E)-3-(2,4-Dichlorophenyl)-1-(4-nitrophenyl)prop-2-en-1-one (CAS 170938-99-5)
- 2-(Phenylthio)pentan-3-one (CAS 27872-70-4)
- 4,8-Dimethoxy-1-vinyl-9H-pyrido[3,4-b]indole (CAS 65236-62-6)
- (1-Phenylcyclopentyl)(4-phenylpiperazin-1-yl)methanone (CAS 1023535-20-7)
- 5-Chloro-2-vinylbenzoic acid (CAS 1467773-21-2)
- (2-(Difluoromethyl)-5-methylphenyl)(pyridin-4-yl)methanone (CAS 1261729-60-5)
- 3-Chlorooctan-4-one (CAS 101251-85-8)
- 4-(1H-pyrrol-1-yl)piperidine (CAS 169751-01-3)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
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