Indoxacarb Impurity 1 CAS 133001-07-7
| CAS No. | 133001-07-7 |
| Molecular Formula | C17H13ClFN3O |
| Molecular Weight | 329.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Indoxacarb Impurity 1.
Indoxacarb Impurity 1 (CAS 133001-07-7) is a certified pharmaceutical impurity reference standard with the molecular formula C17H13ClFN3O and a molecular weight of 329.76 g/mol.
The molecular framework of Indoxacarb Impurity 1 (C17H13ClFN3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H13ClFN3O |
| Molecular Weight | 329.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Indoxacarb Standards
Recommended Standards
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- Furosemide Amide Impurity (CAS 4793-47-9)
- Vericiguat Impurity 67 (CAS 2755814-39-0)
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- Oseltamivir impurity 289 (CAS 1443055-47-7)
- 1-(Tetrahydrofuran-2-yl)butane-1,3-dione (CAS 860705-06-2)
- (S)-2-Amino-N-(2-fluorobenzyl)-N-methylpropanamide (CAS 1292939-22-0)
- 2-((2-Benzoyl-4-chlorophenyl)(cyclopropylmethyl)amino)-2-oxoacetic acid (CAS 33453-17-7)
- 4-(3-Fluoro-4-methylbenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one (CAS 618074-00-3)
- 2-((1-Bromonaphthalen-2-yl)oxy)acetohydrazide (CAS 315248-38-5)
- N-Hydroxy-2-[(2-hydroxyethyl)(methyl)amino]-benzenecarboximidamide (CAS 1216330-09-4)
- Semaglutide impurity 255 (CAS CATO-C4X-2226255)
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