Atorvastatin Impurity 154 CAS 1331869-19-2
| CAS No. | 1331869-19-2 |
| Molecular Formula | C26H22FNO3 |
| Molecular Weight | 415.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 415.46 g/mol gives Atorvastatin Impurity 154 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Atorvastatin Impurity 154 (CAS 1331869-19-2, C26H22FNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Atorvastatin Impurity 154 (C26H22FNO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atorvastatin Impurity 154 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H22FNO3 |
| Molecular Weight | 415.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Atorvastatin Standards
- Atorvastatin Impurity 104 (CAS CATO-C4X-1132104)
- Atorvastatin Impurity 103 (CAS 1797905-42-0)
- Atorvastatin Oxirane Impurity (CAS 1246818-88-1)
- Atorvastatin Impurity 82 (CAS 125971-96-2)
- Atorvastatin Impurity 145 (CAS CATO-C4X-1132145)
- Atorvastatin Impurity 26 (CAS 444577-70-2)
- Atorvastatin EP Impurity D (CAS 148146-51-4)
- Atorvastatin Impurity 124 (CAS 666714-64-3)
Recommended Standards
- Moxifloxacin Hydrochloride EP Impurity C (CAS 1029364-75-7)
- Tegoprazan Impurity 81 (CAS CATO-C4X-229781)
- Moxifloxacin EP Impurity F (CAS 721970-37-2)
- Oxacillin Impurity 57 (CAS CATO-C4X-232157)
- Pranoprofen Impurity 34 (CAS 2688845-71-6)
- Tenofovir Impurity 74 (CAS 1796539-83-7 (free base))
- Lornoxicam impurity 87 (CAS CATO-C4X-201687)
- 4-Isopropyl-1-methyl-1H-pyrazole-5-carbaldehyde (CAS 1781211-50-4)
- 4-(2-Bromophenyl)pyridine (CAS 101681-34-9)
- N-(piperidin-3-ylmethyl)benzenesulfonamide hydrochloride (CAS 1835934-23-0)
- 7-Chloro-1-propyl-1H-benzo[d]imidazol-2-amine (CAS 945024-43-1)
- 4-Ethoxy-2,3-difluorocinnamic acid (CAS 1017779-66-6)
- Arzoxifene HCl (CAS 182133-27-3)
- Tirzepatide Impurity 13 (CAS CATO-C4X-324013)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com