Losartan EP Impurity F CAS 1332713-64-0
| CAS No. | 1332713-64-0 |
| Molecular Formula | C25H29ClN6O |
| Molecular Weight | 464.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Losartan EP Impurity F (CAS 1332713-64-0, C25H29ClN6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Losartan EP Impurity F (C25H29ClN6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H29ClN6O |
| Molecular Weight | 464.99 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Losartan Standards
- Losartan EP Impurity J (CAS 1006062-27-6)
- Losartan Impurity 39 (CAS CATO-C4X-168339)
- Losartan Impurity 40 (CAS CATO-C4X-168340)
- Losartan Impurity 41 (CAS CATO-C4X-168341)
- Losartan Impurity 38 (CAS CATO-C4X-168338)
- Losartan Impurity 21 (CAS 727718-93-6)
- Losartan Impurity 50 (CAS CATO-C4X-168350)
- Losartan Carboxylic Acid-d4 (CAS 1246820-62-1)
Recommended Standards
- N-((4-allyl-5-((3-methoxybenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)-4-chlorobenzenesulfonamide (CAS 338422-27-8)
- Tianeptine Sodium EP Impurity B (CAS 66981-77-9)
- Methyl 3-((4-(5-chloro-2-methylphenyl)piperazin-1-yl)sulfonyl)benzo[b]thiophene-2-carboxylate (CAS 899725-40-7)
- 4-({[(4-chlorophenyl)methyl]sulfanyl}methyl)-6-[(4-methoxyphenyl)sulfanyl]-2-phenylpyrimidine (CAS 338960-76-2)
- Iobitridol Impurity 28 (CAS CATO-C4X-317828)
- Timolol EP Impurity F (CAS 30165-96-9)
- Solriamfetol Impurity 11 (CAS CATO-C4X-256311)
- tert-Butyl (S)-3-(2-fluorobenzyl)piperazine-1-carboxylate (CAS 1240590-08-2)
- 5-(Hydroxymethyl)-6-methylpyridin-2-ol (CAS 1227594-54-8)
- <SC>L</SC>-Cysteine methyl ester hydrochloride (CAS 18598-63-5)
- 2-Chloro-5-nitrobenzenesulfonic acid (CAS 96-73-1)
- 4-Chloro-4'-methyl-1,1'-biphenyl (CAS 19482-11-2)
- 4-Oxo-4-(4-phenoxyphenyl)butanoic acid (CAS 36330-86-6)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
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