Timolol EP Impurity F CAS 30165-96-9
| CAS No. | 30165-96-9 |
| Molecular Formula | C6H8ClN3OS |
| Molecular Weight | 205.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Timolol EP Impurity F (CAS 30165-96-9) is a certified pharmaceutical impurity reference standard with the molecular formula C6H8ClN3OS and a molecular weight of 205.67 g/mol.
Structurally, Timolol EP Impurity F (C6H8ClN3OS) contains an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 205.67 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Timolol EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8ClN3OS |
| Molecular Weight | 205.67 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Timolol Standards
- Timolol EP Impurity G (K salt) (CAS 79844-78-3)
- Timolol EP Impurity G (CAS 75202-36-7)
- Timolol EP Impurity D (CAS 30165-97-0)
- Timolol Impurity 27 (CAS CATO-C4X-149627)
- Timolol Impurity 7 (CAS 30315-49-2)
- Timolol Impurity 16 (CAS 214691-24-4)
- Timolol Impurity 14 (CAS 58827-68-2)
- Timolol Impurity 15 (CAS 949293-84-9)
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- 2-Chloro-6-(difluoromethyl)pyridin-3-ol (CAS 1806759-97-6)
- 2-(2-Methylpyrimidin-4-yl)acetic acid (CAS 933683-32-0)
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