Sofosbuvir Impurity 70 CAS 1334513-02-8
| CAS No. | 1334513-02-8 |
| Molecular Formula | C18H17F5NO5P |
| Molecular Weight | 453.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Sofosbuvir Impurity 70 (CAS 1334513-02-8) is a certified pharmaceutical impurity reference standard with the molecular formula C18H17F5NO5P and a molecular weight of 453.30 g/mol.
Structurally, Sofosbuvir Impurity 70 (C18H17F5NO5P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.5, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 453.30 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sofosbuvir Impurity 70 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H17F5NO5P |
| Molecular Weight | 453.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Sofosbuvir Standards
- Sofosbuvir Impurity N40 (CAS 1256490-52-4)
- Sofosbuvir Impurity 120 (CAS 2190510-88-2)
- Sofosbuvir Impurity 39 (CAS 1496551-91-7)
- Sofosbuvir Impurity 57 (CAS 1337529-56-2)
- Sofosbuvir Impurity 58 (CAS 1714114-25-6)
- Sofosbuvir Impurity 59 (CAS 1627824-09-2)
- Sofosbuvir Impurity 64 (CAS CATO-C4X-105264)
- Sofosbuvir Impurity 87 (CAS 157037-56-4)
Recommended Standards
- Ethyl 4-bromo-6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate (CAS 1445993-96-3)
- (E)-[2-(Benzenesulfonyl)-2-(6-chloropyridin-3-yl)ethylidene][(2-chloro-4-fluorophenyl)methoxy]amine (CAS 478048-60-1)
- (E)-N-((2-(2-fluorophenyl)hydrazono)methyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 400081-42-7)
- 1-(4-Bromophenyl)-5-(furan-2-ylmethylene)-3-phenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (CAS 414908-02-4)
- Paliperidone Impurity 83 HCl (CAS CATO-C4X-172483)
- Rosuvastatin Impurity 234 (CAS CATO-C4X-1169234)
- Fedratinib Impurity 6 (CAS 936091-39-3)
- 3-Methyl-4-({[(pyridin-3-yl)methyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one (CAS 338975-75-0)
- 2-{imidazo[1,2-a]pyrimidin-2-yl}ethan-1-amine hydrobromide (CAS 1365836-55-0)
- Dalilesen Impurity 61 (CAS CATO-C4X-301061)
- 1-(4-(Benzyloxy)phenyl)-2,2,2-trifluoroethan-1-ol (CAS 137615-36-2)
- Indolizin-7-ol (CAS 470477-71-5)
- 1171526-62-7 4-Bromo-3,5-dimethyl-1-(2-methylpropyl)-1H-pyrazole DTXSID50649266 (CAS 1171526-62-7)
- [His]1+12-Semaglutide (CAS CATO-C4X-2226178)
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