Sofosbuvir Impurity 120 CAS 2190510-88-2
| CAS No. | 2190510-88-2 |
| Molecular Formula | C18H17F5NO5P |
| Molecular Weight | 453.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Sofosbuvir Impurity 120 (CAS 2190510-88-2), a pharmacopoeial impurity reference standard (molecular formula C18H17F5NO5P, MW 453.30 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Sofosbuvir Impurity 120 (C18H17F5NO5P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H17F5NO5P |
| Molecular Weight | 453.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Sofosbuvir Standards
- Sofosbuvir Impurity N40 (CAS 1256490-52-4)
- Sofosbuvir Impurity 39 (CAS 1496551-91-7)
- Sofosbuvir Impurity 57 (CAS 1337529-56-2)
- Sofosbuvir Impurity 58 (CAS 1714114-25-6)
- Sofosbuvir Impurity 59 (CAS 1627824-09-2)
- Sofosbuvir Impurity 70 (CAS 1334513-02-8)
- Sofosbuvir Impurity 64 (CAS CATO-C4X-105264)
- Sofosbuvir Impurity 87 (CAS 157037-56-4)
Recommended Standards
- Ethyl (3-(4-chlorophenyl)-8-((4-chlorophenyl)amino)pyrido[2,3-b]pyrazin-6-yl)carbamate (CAS 21395-43-7)
- Etravirine impurity 11 (CAS CATO-C4X-135611)
- Etravirine impurity 10 (CAS CATO-C4X-135610)
- Linagliptin Impurity 80 (CAS 2446799-71-7)
- Betacarotene impurity 9 (CAS 3917-41-7)
- Cefazolin Impurity 75 (CAS CATO-C4X-157775)
- Fluvoxamine EP Impurity J (CAS 1217241-15-0)
- 4-(3-Chlorophenyl)-1H-imidazole (CAS 912763-45-2)
- (s)-2-Amino-2-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-ol (CAS 1213413-72-9)
- 2-(5-Isopropyl-1H-pyrazol-1-yl)acetic acid (CAS 1421760-43-1)
- 5-(Thiophen-2-yl)nicotinic acid (CAS 306934-96-3)
- 2-Chloro-6-iodo-3-(methoxy)pyridine-d3 (CAS 2243517-58-8)
- 3-Bromo-5-hydroxybenzyl Alcohol (CAS 1020336-51-9)
- Tau Peptide (307-321) trifluoroacetate salt (CAS 330456-50-3)
Why CATO?
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