Propofol EP Impurity N CAS 13423-73-9
| CAS No. | 13423-73-9 |
| Molecular Formula | C13H18O3 |
| Molecular Weight | 222.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C13H18O3, Propofol EP Impurity N contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 222.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Propofol EP Impurity N (CAS 13423-73-9, C13H18O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18O3 |
| Molecular Weight | 222.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
Related Propofol Standards
- Propofol Impurity 21 (CAS 153752-00-2)
- Propofol Impurity 32 (CAS 161070-01-5)
- Propofol Impurity 33 (CAS CATO-C4X-147333)
- Propofol Impurity 35 (CAS 2215-21-6)
- Propofol Impurity 39 (CAS 100482-27-7)
- Propofol Impurity 46 (CAS CATO-C4X-147346)
- Propofol Impurity 48 (CAS CATO-C4X-147348)
- Propofol Impurity 59 (CAS CATO-C4X-147359)
Recommended Standards
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- Perindopril EP Impurity K (CAS 2165676-00-4)
- Tigecycline Impurity 13 (CAS CATO-C4X-186013)
- Mirogabalin Impurity 188 (CAS CATO-C4X-2924188)
- Finasteride Impurity 60 HCl (CAS CATO-C4X-164560)
- Methyl (S)-2-amino-2-(3-chlorophenyl)acetate (CAS 1212881-18-9)
- 3,3-Dimethyl-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole (CAS 221352-10-9)
- 4-(2-Methoxyphenoxy)butane-1-sulfonyl chloride (CAS 1339375-35-7)
- Rel-(3R,4R)-3,4-dihydroxydihydrofuran-2(3H)-one (CAS 17675-99-9)
- Amino acid Impurity 18 (CAS 104092-72-0)
- 3-(1,3-Dioxoisoindolin-2-yl)-N-(1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl)propanamide (CAS 896274-91-2)
- (Ser(PO?H?)3??·???)-Tau Peptide (379-408) trifluoroacetate salt (CAS 2022956-60-9)
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