Dexamethasone impurity 90 CAS 134429-31-5
| CAS No. | 134429-31-5 |
| Molecular Formula | C22H28O6 |
| Molecular Weight | 388.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dexamethasone impurity 90 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dexamethasone impurity 90 (CAS 134429-31-5, C22H28O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dexamethasone impurity 90 (C22H28O6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H28O6 |
| Molecular Weight | 388.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
Related Dexamethasone Standards
- Dexamethasone-4¸6α¸21¸21-[d4] (CAS 2483831-63-4)
- Dexamethasone (CAS 50-02-2)
- Dexamethasone EP Impurity A (CAS CATO-C4X-11651)
- Dexamethasone Impurity 62 (CAS CATO-C4X-116562)
- Dexamethasone impurity 67 (CAS CATO-C4X-116567)
- Dexamethasone impurity 68 (CAS CATO-C4X-116568)
- Dexamethasone impurity 69 (CAS CATO-C4X-116569)
- Dexamethasone EP Impurity C (CAS 426-17-5)
Recommended Standards
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- Pimavanserin Impurity 39 (CAS CATO-C4X-193839)
- Mirtazapine EP Impurity C (CAS 191546-96-0)
- Venetoclax Impurity 25 (CAS 2097938-69-5)
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- Raltegravir EthyIEster of Hydrazonic Acid (CAS CATO-C4X-26156)
- (4-(Difluoromethyl)-6-fluoropyridin-2-yl)methanol (CAS 1803665-93-1)
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