Lubiprostone Impurity 17 CAS 136790-73-3
| CAS No. | 136790-73-3 |
| Molecular Formula | C20H30F2O5 |
| Molecular Weight | 388.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution, Lubiprostone Impurity 17 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 388.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lubiprostone Impurity 17 (CAS 136790-73-3, C20H30F2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H30F2O5 |
| Molecular Weight | 388.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
Related Lubiprostone Standards
- Lubiprostone Impurity 27 (CAS CATO-C4X-113627)
- Lubiprostone (CAS 136790-76-6/333963-40-9)
- Lubiprostone Impurity 18 (CAS 201226-21-3)
- Lubiprostone Impurity 3 (CAS 1263283-38-0)
- Lubiprostone Impurity 30 (CAS 2743427-14-5)
- Lubiprostone Impurity 31 (CAS CATO-C4X-113631)
- Lubiprostone Impurity 32 (CAS CATO-C4X-113632)
- Lubiprostone Impurity 33 (CAS CATO-C4X-113633)
Recommended Standards
- 96850-29-2 Kaura-2,16-dien-1-one,15-(acetyloxy)-7,20-epoxy-6,7-dihydroxy-, (6b,7a,15b)- (CAS 96850-29-2)
- 67560-68-3 ((2S,3R,4R)-2-(3,4-Dimethoxyphenyl)-4-((3,4-dimethoxyphenyl)methyl)oxolan-3-yl)methanol DTXSID40217892 (CAS 67560-68-3)
- Dexamethasone impurity 90 (CAS 134429-31-5)
- 40737-92-6 Isocalolongic acid (CAS 40737-92-6)
- Demeclocycline Hydrochloride EP Impurity D (CAS 81181-91-1)
- Baloxavir Impurity 60 (CAS 178461-70-6)
- Paroxetine Hydrochloride Hemihydrate EP Impurity B (CAS 127017-69-0(free base))
- N-(tert-Butyl)-3,5,6-trifluoropyridin-2-amine (CAS 189281-22-9)
- 2-((4-(N-cyclohexyl-N-methylsulfamoyl)phenyl)carbamoyl)cyclohexane-1-carboxylic acid (CAS 817179-89-8)
- Isopyrazam (CAS 881685-58-1)
- Vecuronium Bromide Impurity 10 (CAS 41261-71-6)
- 3,5-Dibromodiphenyl Ether (CAS 46438-88-4)
- 1-(2-(3-Bromophenoxy)ethyl)pyrrolidine (CAS 23136-18-7)
- Semaglutide Impurity 121 X Sodium Salt (CAS CATO-C4X-2226121)
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