Sitagliptin Impurity 7 CAS 1345822-88-9
| CAS No. | 1345822-88-9 |
| Molecular Formula | C16H16F5N5O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 487.32 g/mol gives Sitagliptin Impurity 7 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Sitagliptin Impurity 7 (CAS 1345822-88-9, C16H16F5N5OH3O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sitagliptin Impurity 7 (C16H16F5N5OH3O4P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sitagliptin Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16F5N5O H3O4P |
| Molecular Weight | 487.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin Impurity 17 (CAS 1036273-20-7)
- Sitagliptin Impurity 966 (CAS 1151240-88-8)
- Sitagliptin Impurity 14 (CAS 1151240-91-3)
- Sitagliptin Impurity 12 HCl (CAS 1151240-91-3（free base）)
- Sitagliptin Impurity 77 (CAS 1152439-73-0)
- Sitagliptin Impurity 97 (CAS 1169707-29-2)
- Sitagliptin Tablets EP Impurity FP-E HCl (CAS 1204818-19-8)
- Sitagliptin Impurity 15 (CAS 1217809-78-3)
Recommended Standards
- Cyproheptadine Impurity 2 (CAS 2222-33-5)
- Phloroglucinol Impurity 73 (CAS 112221-65-5)
- Silodosin Depropanol Impurity1 (CAS 2052161-47-2)
- Nβ-Azido-L-2,3-Diaminopropionic Acid (CAS 105661-40-3)
- (Butan-2-yl)[(3,4-dichlorophenyl)methyl]amine (CAS 854181-08-1)
- 4,4,8-Trimethyl-3,4-dihydroquinolin-2(1H)-one (CAS 120689-98-7)
- (4-Bromophenoxy)-tert-butyldimethylsilane 1-Bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzene 4-Bromophenol tert-Butyldimethylsilyl Ether 4-Bromophenyl tert-Butyldimethylsilyl Ether 67963-68-2 (CAS 67963-68-2)
- 【禁售不询】Dimetiltriptamin (CAS 61-50-7)
- 5-Hydroxytetrahydropyrimidin-2(1H)-one (CAS 1852-18-2)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
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