Valaciclovir EP Impurity D CAS 1346747-69-0
| CAS No. | 1346747-69-0 |
| Molecular Formula | C15H24N6O4 |
| Molecular Weight | 352.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Valaciclovir EP Impurity D.
As a process- or degradation-related impurity, Valaciclovir EP Impurity D (CAS 1346747-69-0, C15H24N6O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Valaciclovir EP Impurity D (C15H24N6O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H24N6O4 |
| Molecular Weight | 352.39 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 6 |
Related Valaciclovir Standards
- Valaciclovir EP Impurity M (CAS 847670-62-6)
- Valaciclovir Impurity 36 (CAS 19542-54-2)
- Valaciclovir Impurity 37 (CAS CATO-C4X-124837)
- Valaciclovir Impurity 42 (CAS 73504-31-1)
- Valaciclovir EP Impurity J (CAS 142963-63-1)
- Valaciclovir EP Impurity C (CAS 1346747-65-6)
- Valaciclovir EP Impurity R (CAS 142963-59-5)
- Valaciclovir EP Impurity R (CAS 142963-60-8)
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