Tofacitinib Impurity 71 CAS 134965-85-8
| CAS No. | 134965-85-8 |
| Molecular Formula | C12H7ClN6 |
| Molecular Weight | 270.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tofacitinib Impurity 71 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tofacitinib Impurity 71 (CAS 134965-85-8, C12H7ClN6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tofacitinib Impurity 71 (C12H7ClN6) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H7ClN6 |
| Molecular Weight | 270.68 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 22 (CAS 2227199-28-0)
- Tofacitinib Impurity 111 (CAS 2183519-70-0)
- Tofacitinib Impurity 114 (CAS CATO-C4X-1079114)
- Tofacitinib Impurity 158 (CAS CATO-C4X-1079158)
- Tofacitinib Impurity 203 (CAS CATO-C4X-1079203)
- Tofacitinib Impurity 242 (CAS CATO-C4X-1079242)
- Tofacitinib Nitroso Impurity 187 (CAS CATO-C4X-1079187)
- Tofacitinib Impurity N48 (CAS 1638499-35-0)
Recommended Standards
- 1-[Chloro(phenyl)methyl]-2-(trifluoromethyl)benzene (CAS 881040-67-1)
- Moxonidine impurity 5 (CAS CATO-C4X-27815)
- 1-(Chloro(phenyl)methyl)-4-(trifluoromethyl)benzene (CAS 787-49-5)
- N-Nitroso Moxonidine (CAS CATO-C4X-27816)
- Amisulpride Impurity 11 (CAS 261614-86-2)
- Atrasentan Impurity 128 (CAS 1063835-95-9)
- Spiramycin EP Impurity B (CAS 249930-66-3)
- N'-(3,5-dimethylbenzoyl)-N'-(2,2-dimethylpentan-3-yl)-3-methoxy-2-methylbenzohydrazide (CAS 755013-53-7)
- (2E)-3-{4-Methoxy-3-[(2,2,2-trifluoroethoxy)-methyl]phenyl}acrylic acid (CAS 1119452-77-5)
- (S)-N-(3-(4-Carbamimidoylbenzamido)propyl)-1-((2,4-dichloro-3-(((2,4-dimethylquinolin-8-yl)oxy)methyl)phenyl)sulfonyl)pyrrolidine-2-carboxamide methanesulfonate (CAS 515880-69-0)
- 2-((1H-Indol-3-yl)methyl)-8-bromo-3-hydroxyquinoline-4-carboxylic acid (CAS 924634-63-9)
- 4-((4-Chlorophenyl)sulfonyl)-N-(2-methoxyethyl)-2-(m-tolyl)oxazol-5-amine (CAS 862741-85-3)
- Ethyl 2-(isopropylcarbamoyl)-3-((3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylate (CAS 318237-97-7)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
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