Tofacitinib Impurity N48 CAS 1638499-35-0
| CAS No. | 1638499-35-0 |
| Molecular Formula | C15H17ClN2O |
| Molecular Weight | 276.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Tofacitinib Impurity N48 (CAS 1638499-35-0), a pharmacopoeial impurity reference standard (molecular formula C15H17ClN2O, MW 276.76 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tofacitinib Impurity N48 (C15H17ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 276.76 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Tofacitinib Impurity N48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H17ClN2O |
| Molecular Weight | 276.76 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Nitroso Impurity 187 (CAS CATO-C4X-1079187)
- Tofacitinib Impurity 242 (CAS CATO-C4X-1079242)
- Tofacitinib Nitroso Impurity 188 (CAS CATO-C4X-1079188)
- Tofacitinib Impurity 158 (CAS CATO-C4X-1079158)
- Tofacitinib Impurity 203 (CAS CATO-C4X-1079203)
- Tofacitinib Impurity 230 (CAS CATO-C4X-1079230)
- Tofacitinib Impurity 5 (CAS 1616760-97-4)
- Tofacitinib Impurity 9 (CAS 2250243-18-4)
Recommended Standards
- tert-butyl cis-4-chlorocarbonyl-3,5-dimethyl-piperazine-1-carboxylate (CAS 438050-53-4)
- (2-(((5-Chloro-1,2,3-thiadiazol-4-yl)methyl)thio)-1-methyl-1H-imidazol-5-yl)methanol (CAS 338422-47-2)
- tert-Butyl 4-(2-chloroacetyl)-1,4-diazepane-1-carboxylate (CAS 722537-49-7)
- 3-(4-Isopropylphenoxy)propane-1-sulfonyl chloride (CAS 1018340-69-6)
- Varenicline Impurity 18 (CAS 230615-70-0)
- Fluorescein impurity 01 (CAS 76579-17-4)
- Ruxolitinib Impurity 110 (CAS CATO-C4X-2058110)
- N'-(diphenylmethylene)-2-(phenylthio)acetohydrazide (CAS 341967-99-5)
- 1-(2-(4-Chloro-2-methylphenoxy)-5-fluorophenyl)-N-methylmethanamine (CAS 1096319-05-9)
- (5-chloro-6-methyl-pyrazin-2-yl)methanamine (CAS 1260665-35-7)
- Esomeprazole Impurity 106 (CAS 110464-72-7)
- Methyl 3-iodo-4-oxo-2-(trifluoromethyl)-4H-pyrido[1,2-a]pyrimidine-8-carboxylate (CAS 2648773-73-1)
- Dihydrostreptomycin (CAS 128-46-1)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com