Tofacitinib Impurity 242 CAS CATO-C4X-1079242
| CAS No. | CATO-C4X-1079242 |
| Molecular Formula | C14H21N5O |
| Molecular Weight | 275.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 242.
CATO supplies Tofacitinib Impurity 242 (CAS CATO-C4X-1079242), a pharmacopoeial impurity reference standard (molecular formula C14H21N5O, MW 275.35 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tofacitinib Impurity 242 (C14H21N5O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tofacitinib Impurity 242 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H21N5O |
| Molecular Weight | 275.35 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Nitroso Impurity 187 (CAS CATO-C4X-1079187)
- Tofacitinib Impurity 158 (CAS CATO-C4X-1079158)
- Tofacitinib Impurity 203 (CAS CATO-C4X-1079203)
- Tofacitinib Impurity N48 (CAS 1638499-35-0)
- Tofacitinib Impurity 111 (CAS 2183519-70-0)
- Tofacitinib Impurity 114 (CAS CATO-C4X-1079114)
- Tofacitinib Impurity 22 (CAS 2227199-28-0)
- Tofacitinib Nitroso Impurity 188 (CAS CATO-C4X-1079188)
Recommended Standards
- Tirofiban Impurity 90 (CAS 5421-79-4)
- Apixaban Impurity 79 (CAS 2435783-75-6)
- tert-Butyl 6-amino-3',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate (CAS 478366-41-5)
- Ropivacaine Impurity 27 (CAS CATO-C4X-175327)
- Sevoflurane Impurity 8 (CAS 79507-76-9)
- Mianserin Impurity 49 (CAS CATO-C4X-136949)
- Relugolix Impurity N4 (CAS 1589503-97-8)
- 1-(Methylamino)cyclopropane-1-carbonitrile (CAS 1698290-52-6)
- 2-amino-2-(oxolan-3-yl)acetic acid (CAS 1169930-49-7)
- Amicarbazone (CAS 129909-90-6)
- 2-Phenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione (CAS 2221-09-2)
- 5-(4-Fluorophenyl)-3-methylisoxazole (CAS 70862-53-2)
- N-(2-(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)ethyl)-2,3-dihydroxy-5-nitrobenzamide (CAS 273204-43-6)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
Why CATO?
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