Losartan Impurity N2 CAS 1351793-76-4
| CAS No. | 1351793-76-4 |
| Molecular Formula | C19H18N4O5 |
| Molecular Weight | 382.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Losartan Impurity N2 (CAS 1351793-76-4) is a certified pharmaceutical impurity reference standard with the molecular formula C19H18N4O5 and a molecular weight of 382.37 g/mol.
Losartan Impurity N2 (C19H18N4O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H18N4O5 |
| Molecular Weight | 382.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 4 |
Related Losartan Standards
- Losartan Impurity 37 (CAS CATO-C4X-168337)
- Losartan Impurity 15 (CAS 114772-55-3)
- Losartan Impurity 29 (CAS 2204369-11-7)
- Losartan Impurity 51 (CAS CATO-C4X-168351)
- Losartan Impurity 61 (CAS CATO-C4X-168361)
- Losartan Impurity 28 (CAS 124750-67-0)
- Losartan Impurity 57 (CAS C4X-13305)
- Losartan Impurity 49 (CAS CATO-C4X-168349)
Recommended Standards
- Yttrium-Nickel alloy, YNi5 99.9% trace metals basis (CAS 12333-67-4)
- (S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide (CAS 146118-22-1)
- Bis(2,5-dioxopyrrolidin-1-yl) nonanedioate (CAS 106664-96-4)
- N-(6-Amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-2-hydroxy-5-methoxybenzamide (CAS 176379-31-0)
- Eldecalcitol Impurity 42 (CAS 213250-68-1)
- Vardenafil EP Impurity A (CAS 2169247-39-4)
- Rabeprazole Impurity 33 (CAS 924663-39-8（free base）)
- 4-Methoxy-2-phenylpyridine (CAS 53698-56-9)
- 4-Cyclopropoxy-6-(methylthio)pyridine-2-sulfonamide (CAS 1243350-85-7)
- 1-Isopropyl-2-methyl-1H-indole-3-carbaldehyde (CAS 592550-38-4)
- 2,2-Difluoro-2-mesitylacetic Acid (CAS 1436389-32-0)
- ethyl 4-chloro-6-(trifluoromethyl)pyridine-3-carboxylate (CAS 1196146-35-6)
- 2-(Difluoromethyl)-6-methoxy-4-methylpyridine-3-sulfonamide (CAS 1805066-37-8)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
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