Valsartan Impurity 56 CAS 1353844-75-3
| CAS No. | 1353844-75-3 |
| Molecular Formula | C33H31N9O2 |
| Molecular Weight | 585.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Valsartan Impurity 56 (CAS 1353844-75-3, C33H31N9O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Valsartan Impurity 56 (C33H31N9O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H31N9O2 |
| Molecular Weight | 585.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 23.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 9 |
Related Valsartan Standards
- Valsartan Impurity 107 (CAS CATO-C4X-1057107)
- Valsartan Impurity 81 (CAS CATO-C4X-105781)
- Valsartan Impurity 25 (CAS 133051-88-4)
- Valsartan Impurity 29 (CAS 124750-51-2)
- 4-Oxo Valsartan Benzyl Ester (CAS 188240-32-6)
- Valsartan Impurity 28 (CAS 154709-17-8)
- Valsartan Impurity 45 (CAS 358685-13-9)
- Valsartan Impurity 150 (CAS CATO-C4X-1057150)
Recommended Standards
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