Roflumilast Impurity 34 CAS 1882067-44-8
| CAS No. | 1882067-44-8 |
| Molecular Formula | C12H12F2O4 |
| Molecular Weight | 258.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Roflumilast Impurity 34.
CATO supplies Roflumilast Impurity 34 (CAS 1882067-44-8), a pharmacopoeial impurity reference standard (molecular formula C12H12F2O4, MW 258.22 g/mol) used for the identification and quantification of trace impurities in APIs.
Roflumilast Impurity 34 (C12H12F2O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Roflumilast Impurity 34 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H12F2O4 |
| Molecular Weight | 258.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related Roflumilast Standards
- Roflumilast impurity 15 (CAS 162401-69-6)
- Roflumilast Impurity 33 (CAS 2376345-94-5)
- Roflumilast USP Related Compound D (CAS 162401-62-9)
- Roflumilast Impurity 44 (CAS CATO-C4X-108444)
- Roflumilast Impurity C65 (CAS 162401-60-7)
- Roflumilast Impurity 58 (CAS CATO-C4X-193558)
- Roflumilast Impurity 43 (CAS CATO-C4X-108443)
- Roflumilast impurity 23 (CAS 1369817-76-4)
Recommended Standards
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- Methyl 3-4-di-O-acetyl-D-glucuronal (CAS 57690-62-7)
- Eperisone Impurity 41 (CAS CATO-C4X-227941)
- Famotidine impurity 76 (CAS CATO-C4X-139276)
- Sitafloxacin Impurity 49 (CAS 129306-06-5)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com