Betahistine Impurity 27 CAS 26832-29-1
| CAS No. | 26832-29-1 |
| Molecular Formula | C9H14N2 |
| Molecular Weight | 150.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Betahistine Impurity 27 (C9H14N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Betahistine Impurity 27 (CAS 26832-29-1) is a certified pharmaceutical impurity reference standard with the molecular formula C9H14N2 and a molecular weight of 150.22 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H14N2 |
| Molecular Weight | 150.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Nitrogen Atoms | 2 |
Related Betahistine Standards
- Betahistine impurity 41 (CAS 113985-59-4)
- Betahistine impurity N3 (CAS 562101-24-0)
- Betahistine impurity 33 (CAS 13585-92-7)
- Betahistine Impurity 22 (CAS 49745-42-8)
- Betahistine Impurity 03 (CAS 88780-61-4)
- Betahistine (CAS 5638-76-6)
- Betahistine Impurity 19 (CAS 32635-81-7)
- Betahistine impurity 37 (CAS CATO-C4X-183837)
Recommended Standards
- 5-isopropylbicyclo[3.1.0]hex-2-ene-2-carbaldehyde (CAS 57129-54-1)
- 2-(2-Dimethylaminoethyl)pyridine (CAS 6304-27-4)
- Loxoprofen Impurity 49 (CAS 825-25-2)
- Dyclonine Impurity 6 (CAS 3180-09-4)
- Piperazine Impurity 66 (CAS CATO-C4X-242766)
- Eltrombopag Impurity 20 (CAS 376591-94-5)
- Atogepant Impurity 27 (CAS 957122-47-3)
- N-(2-Bromo-4,6-difluorophenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 577982-37-7)
- 1-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-N-[(4-methylphenyl)methyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 321848-19-5)
- Lisinopril Impurity N (CAS 103300-91-0)
- 4-(4-Boc-Piperazino)-2-chlorophenylboronic acid (CAS 2377608-54-1)
- 4-Isopropoxy-6-(4-methoxyphenyl)-2-phenylpyrimidine-5-carbonitrile (CAS 338395-02-1)
- Methanone, (4-nitrophenyl)phenyl-, oxime (CAS 38032-13-2)
- Osteogenic Growth Peptide (10-14) (CAS 105250-85-9)
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