Lamivudine EP Impurity B ((2S,5S)-Isomer) CAS 136846-20-3
| CAS No. | 136846-20-3 |
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Lamivudine EP Impurity B ((2S,5S)-Isomer) (CAS 136846-20-3) is a certified pharmaceutical impurity reference standard with the molecular formula C8H11N3O3S and a molecular weight of 229.26 g/mol.
Structurally, Lamivudine EP Impurity B ((2S,5S)-Isomer) (C8H11N3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 229.26 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lamivudine Standards
- Lamivudine Impurity B (CAS 141434-39-1)
- Lamivudine (CAS 134678-17-4)
- Lamivudine Impurity B((2R,5R)-Isomer) (CAS 139757-68-9)
- Lamivudine Impurity 24 (CAS CATO-C4X-119424)
- Lamivudine EP Impurity D (Ent-Lamivudine) (CAS 134680-32-3)
- Lamivudine Impurity J (CAS 131086-26-5)
- Lamivudine EP Impurity J (CAS 145986-07-8)
- Lamivudine Impurity 19 (CAS 953806-67-2)
Recommended Standards
- Ceftazidime Impurity 88 (CAS CATO-C4X-121288)
- N,N-Dimethylnicotinamide-2-sulfonamide (CAS 112006-75-4)
- Ticagrelor Impurity 62 (CAS CATO-C4X-109362)
- Dimethoate (CAS 60-51-5)
- Glycerol Impurity 48 (CAS CATO-C4X-217148)
- Emtricitabine Impurity 11 (CAS 145281-92-1)
- Carbazochrome Impurity 36 (CAS CATO-C4X-229136)
- 1-(piperidin-3-yl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride (CAS 1909326-32-4)
- (2E)-3-(2,3-Dihydro-1,4-benzodioxin-5-yl)prop-2-enoic acid (CAS 347342-38-5)
- 4-Ethyl-N-methyloctan-1-amine (CAS 1272935-67-7)
- 5-(1-acetamidoethyl)thiophene-2-sulfonyl chloride (CAS 1016749-39-5)
- 2-(Dimethylamino)quinolin-4(1H)-one (CAS 60137-10-2)
- 5-[(2,5-Dichlorophenoxy)methyl]-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 861240-03-1)
- Semaglutide impurity 29 (CAS 1188328-22-4)
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