Lamivudine Impurity B CAS 141434-39-1
| CAS No. | 141434-39-1 |
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lamivudine Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lamivudine Impurity B (CAS 141434-39-1, C8H11N3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lamivudine Impurity B (C8H11N3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 229.26 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lamivudine Standards
- Lamivudine (CAS 134678-17-4)
- Lamivudine Impurity B((2R,5R)-Isomer) (CAS 139757-68-9)
- Lamivudine Impurity 24 (CAS CATO-C4X-119424)
- Lamivudine EP Impurity B ((2S,5S)-Isomer) (CAS 136846-20-3)
- Lamivudine EP Impurity D (Ent-Lamivudine) (CAS 134680-32-3)
- Lamivudine Impurity J (CAS 131086-26-5)
- Lamivudine EP Impurity J (CAS 145986-07-8)
- Lamivudine Impurity 19 (CAS 953806-67-2)
Recommended Standards
- 2-((4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl)oxy)acetic acid (CAS 1399664-25-5)
- 2-(2-{[Amino(imino)methyl]amino}-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)-N-methylacetamide (CAS 1428139-96-1)
- 6-(Pyridin-3-yl)imidazo[2,1-b]thiazole-5-carbaldehyde (CAS 139359-79-8)
- N'-hydroxy-4-[(methylsulfonyl)amino]benzenecarboximidamide (CAS 148459-01-2)
- Anlotinib Impurity 3 (CAS CATO-C4X-32833)
- Tofacitinib Impurity 243 (CAS CATO-C4X-1079243)
- Cephalosporin Impurity 2 (CAS 1269661-23-5)
- 1245914-35-5 3-Bromo-5-fluoro-2-(trifluoromethyl)pyridine (CAS 1245914-35-5)
- (R)-2-((tert-butoxycarbonyl)amino)-3-ethylpentanoic acid (CAS 1310680-39-7)
- N-(Trimethylsilyl)methanesulfonamide (CAS 999-96-2)
- 3-Mercapto-2-methylbenzoic acid (CAS 188700-62-1)
- 2-bromo-3-fluoro-4-methylaniline (CAS 1510652-64-8)
- 4-(Isoindolin-2-yl)-2-methylbenzaldehyde (CAS 347325-40-0)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
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