Lamivudine EP Impurity D (Ent-Lamivudine) CAS 134680-32-3
| CAS No. | 134680-32-3 |
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lamivudine EP Impurity D (Ent-Lamivudine) is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Lamivudine EP Impurity D (Ent-Lamivudine) (CAS 134680-32-3) is a certified pharmaceutical impurity reference standard with the molecular formula C8H11N3O3S and a molecular weight of 229.26 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Lamivudine EP Impurity D (Ent-Lamivudine) is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 229.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lamivudine EP Impurity D (Ent-Lamivudine) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lamivudine Standards
- Lamivudine Impurity B (CAS 141434-39-1)
- Lamivudine (CAS 134678-17-4)
- Lamivudine Impurity B((2R,5R)-Isomer) (CAS 139757-68-9)
- Lamivudine Impurity 24 (CAS CATO-C4X-119424)
- Lamivudine EP Impurity B ((2S,5S)-Isomer) (CAS 136846-20-3)
- Lamivudine Impurity J (CAS 131086-26-5)
- Lamivudine EP Impurity J (CAS 145986-07-8)
- Lamivudine Impurity 19 (CAS 953806-67-2)
Recommended Standards
- Ceftazidime Impurity 88 (CAS CATO-C4X-121288)
- N,N-Dimethylnicotinamide-2-sulfonamide (CAS 112006-75-4)
- Dimethoate (CAS 60-51-5)
- Isodimethoate (CAS 3344-11-4)
- Suvorexant Impurity 11 (CAS 1307296-61-2)
- Betamethasone Impurity 28 (CAS CATO-C4X-143728)
- Revefenacin Impurity 63 (CAS CATO-C4X-203163)
- Argatroban Impurity 88 (CAS CATO-C4X-100788)
- 2-(3,3-Difluoropiperidin-1-yl)nicotinaldehyde (CAS 1774895-41-8)
- Acetyl-D-isoleucine (CAS 19764-31-9)
- 2-(2-Ethyl-1h-imidazol-1-yl)benzoic acid (CAS 159589-72-7)
- Methyl 5-bromo-4-(hydroxymethyl)-2-methoxybenzoate (CAS 1075281-20-7)
- 1,8-Dichloroanthracene (CAS 14381-66-9)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
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