Lemborexant Impurity 33 CAS 1369765-94-5
| CAS No. | 1369765-94-5 |
| Molecular Formula | C22H20F2N4O3 |
| Molecular Weight | 426.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lemborexant Impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lemborexant Impurity 33 (CAS 1369765-94-5, C22H20F2N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lemborexant Impurity 33 (C22H20F2N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 426.42 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H20F2N4O3 |
| Molecular Weight | 426.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Lemborexant Standards
- Lemborexant Impurity 22 (CAS 1369765-96-7)
- Lemborexant Impurity 34 (CAS 1369765-95-6)
- Lemborexant Impurity 35 (CAS CATO-C4X-304235)
- Lemborexant impurity 15 (CAS CATO-C4X-304215)
- Lemborexant Impurity 105 (CAS CATO-C4X-3042105)
- Lemborexant Impurity 31 (CAS CATO-C4X-304231)
- Lemborexant-d6 (CAS CATO-C4X-304267)
- Lemborexant Impurity 21 (CAS CATO-C4X-304221)
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- Famotidine-13C,d4 Acid Impurity (CAS 1324230-60-5)
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