Larotrectinib Impurity 16 CAS 2699151-02-3
| CAS No. | 2699151-02-3 |
| Molecular Formula | C21H20F2N6O2 |
| Molecular Weight | 426.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Larotrectinib Impurity 16 (CAS 2699151-02-3), a pharmacopoeial impurity reference standard (molecular formula C21H20F2N6O2, MW 426.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Larotrectinib Impurity 16 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 426.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Larotrectinib Impurity 16 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H20F2N6O2 |
| Molecular Weight | 426.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Larotrectinib Standards
- Larotrectinib (CAS 1223403-58-4)
- Larotrectinib Impurity 1 (CAS 1223404-68-9)
- Larotrectinib Impurity 2 (CAS 2409589-59-7)
- Larotrectinib Impurity 3 (CAS 2409590-08-3)
- Larotrectinib Impurity 15 (CAS CATO-C4X-238015)
- Larotrectinib impurity 5 (CAS 2135871-21-3)
- Larotrectinib impurity 9 (CAS CATO-C4X-23809)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
Recommended Standards
- Tetracycline EP Impurity D (CAS 7518-17-4)
- Lemborexant Impurity 22 (CAS 1369765-96-7)
- Tetracycline EP Impurity C (CAS 1665-56-1)
- Lemborexant Impurity 33 (CAS 1369765-94-5)
- Betamethasone impurity 72 (CAS CATO-C4X-143772)
- Apremilast Impurity 40 (CAS 2055542-18-0)
- Penehyclidine Impurity 3 (CAS 2091937-84-5)
- 5-(trifluoromethyl)thiophene-2-sulfonamide (CAS 519055-80-2)
- 3-(Piperidin-1-yl)propanethioamide (CAS 16888-42-9)
- Zolmitriptan Sulfonamide Impurity (CAS 1346602-02-5)
- 5-(Chloromethyl)-1-(4-ethoxyphenyl)-1H-tetrazole (CAS 552814-58-1)
- 1-(3-Methylbenzyl)-1H-benzo[d]imidazole-2-carbaldehyde (CAS 615281-47-5)
- Methyl 2-azabicyclo[2.1.1]hexane-1-carboxylate hydrochloride (CAS 1392803-66-5)
- (Tyr9)-Cholecystokinin Octapeptide (sulfated) (H-9770.0005) (CAS 96607-61-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com