Niraparib Impurity 6 CAS 1369926-38-4
| CAS No. | 1369926-38-4 |
| Molecular Formula | C8H4N2O4 |
| Molecular Weight | 192.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Niraparib Impurity 6 (CAS 1369926-38-4, C8H4N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Niraparib Impurity 6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 192.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4N2O4 |
| Molecular Weight | 192.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 2 |
Related Niraparib Standards
- Niraparib Impurity 7 (CAS 1289162-62-4)
- Niraparib Impurity 56 (CAS 1090871-88-7)
- Niraparib Impurity 66 (CAS CATO-C4X-232966)
- Niraparib Impurity 8 (CAS 1289174-44-2)
- Niraparib Impurity 14 (CAS CATO-C4X-232914)
- Niraparib Impurity 9 (CAS CATO-C4X-23299)
- Niraparib Impurity 16 (CAS CATO-C4X-232916)
- Niraparib Impurity 12 (CAS CATO-C4X-232912)
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