Niraparib Impurity 8 CAS 1289174-44-2
| CAS No. | 1289174-44-2 |
| Molecular Formula | C8H5NO5 |
| Molecular Weight | 195.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Niraparib Impurity 8.
Niraparib Impurity 8 (CAS 1289174-44-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H5NO5 and a molecular weight of 195.13 g/mol.
Niraparib Impurity 8 (C8H5NO5) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5NO5 |
| Molecular Weight | 195.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 1 |
Related Niraparib Standards
- Niraparib Impurity 7 (CAS 1289162-62-4)
- Niraparib Impurity 6 (CAS 1369926-38-4)
- Niraparib Impurity 9 (CAS CATO-C4X-23299)
- Niraparib Impurity 56 (CAS 1090871-88-7)
- Niraparib Impurity 66 (CAS CATO-C4X-232966)
- Niraparib Impurity 12 (CAS CATO-C4X-232912)
- Niraparib Impurity 14 (CAS CATO-C4X-232914)
- Niraparib Impurity 57 (CAS 343778-18-7)
Recommended Standards
- Tadalafil Impurity 131 (CAS 209120-51-4)
- 1-((2,2,2-Trifluoroethoxy)methyl)-1h-pyrazol-4-amine (CAS 1004643-33-7)
- Apremilast Impurity 86 (CAS 106860-70-2)
- 3-Methoxy-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-amine (CAS 1006462-54-9)
- Latamoxef Impurity 48 (CAS CATO-C4X-179848)
- Bortezomib Impurity 34 (CAS 862895-00-9)
- Apremilast impurity 16 (CAS 1384439-80-8)
- Indacaterol Impurity 8 (CAS 435273-75-9)
- 1,3,5,7-tetrakis(4-formylphenyl)adamantane (CAS 645401-15-6)
- 3-(5-(Benzyloxy)-2,4-dichlorophenyl)-2-(benzylthio)quinazolin-4(3H)-one (CAS 400087-06-1)
- 6-chlorofuro[2,3-b]pyridine-2-carboxylic acid (CAS 66497-40-3)
- 5-(Pyrazin-2-yl)-1H-pyrazole-3-carboxylic acid (CAS 1029108-75-5)
- 2-Aminobenzene-1-sulfonyl fluoride (CAS 392-86-9)
- Acetyl-(Leu28·31)-Neuropeptide Y (24-36) (CAS 155709-24-3)
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