Neratinib Impurity 15 CAS 1376615-55-2
| CAS No. | 1376615-55-2 |
| Molecular Formula | C30H29ClN6O4 |
| Molecular Weight | 573.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Neratinib Impurity 15 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Neratinib Impurity 15 (CAS 1376615-55-2) is a certified pharmaceutical impurity reference standard with the molecular formula C30H29ClN6O4 and a molecular weight of 573.04 g/mol.
Structurally, Neratinib Impurity 15 (C30H29ClN6O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 19.0, corresponding to approximately 19 ring(s) or double-bond equivalent(s). With a molecular weight of 573.04 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Neratinib Impurity 15 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C30H29ClN6O4 |
| Molecular Weight | 573.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Neratinib Standards
- Neratinib Impurity 16 (CAS 1376619-94-1)
- Neratinib Impurity 3 (CAS CATO-C4X-11343)
- Neratinib Impurity 4 (CAS CATO-C4X-11344)
- Neratinib Impurity 49 (CAS 3050754-68-9)
- Neratinib Impurity 19 (CAS 1376619-98-5)
- Neratinib Impurity 35 (CAS CATO-C4X-113435)
- Neratinib-d6 (CAS 1259519-18-0)
- Neratinib Impurity 45 (CAS CATO-C4X-113445)
Recommended Standards
- N-{[(4-chlorophenyl)carbamoyl]amino}-4-[4-(diphenylmethyl)piperazine-1-carbonyl]-5-methyl-1,2-oxazole-3-carboxamide (CAS 338408-78-9)
- 1-(2-(4-Bromo-2-chlorophenoxy)ethyl)-4-((tert-butyldiphenylsilyl)oxy)piperidine (CAS 1704080-89-6)
- 9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-6-chloro-9H-purine (CAS 133931-96-1)
- Amlodipine Impurity 81 (CAS CATO-C4X-109581)
- Flomoxef Impurity 11 (CAS CATO-C4X-138211)
- Cefazolin Impurity 83 (CAS CATO-C4X-157783)
- Baloxavir Impurity 149 (CAS CATO-C4X-2108149)
- 3,3,3-Trifluoropropyl methanesulfonate (CAS 911116-16-0)
- 4'-Chloro-3-hydroxy-5-(trifluoromethyl)-1,1-biphenyl-4-carbonitrile (CAS 147381-62-2)
- 4-Bromo-2-(trifluoromethyl)benzenethiol (CAS 1208075-10-8)
- (1E)-1-(Dimethylamino)-4-methylpent-1-en-3-one (CAS 5782-56-9)
- 1-(4-(Aminomethyl)piperidin-1-yl)pentan-1-one (CAS 1018555-29-7)
- 2-(2-Methyl-1H-benzo[d]imidazol-1-yl)propanoic acid (CAS 753489-92-8)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com