Neratinib Impurity 49 CAS 3050754-68-9
| CAS No. | 3050754-68-9 |
| Molecular Formula | C29H26ClN7O4 |
| Molecular Weight | 572.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 572.01 g/mol gives Neratinib Impurity 49 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Neratinib Impurity 49 (CAS 3050754-68-9) is a certified pharmaceutical impurity reference standard with the molecular formula C29H26ClN7O4 and a molecular weight of 572.01 g/mol.
Structurally, Neratinib Impurity 49 (C29H26ClN7O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 572.01 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H26ClN7O4 |
| Molecular Weight | 572.01 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Neratinib Standards
- Neratinib Impurity 15 (CAS 1376615-55-2)
- Neratinib Impurity 16 (CAS 1376619-94-1)
- Neratinib Impurity 3 (CAS CATO-C4X-11343)
- Neratinib Impurity 4 (CAS CATO-C4X-11344)
- Neratinib Impurity 19 (CAS 1376619-98-5)
- Neratinib Impurity 35 (CAS CATO-C4X-113435)
- Neratinib-d6 (CAS 1259519-18-0)
- Neratinib Impurity 30 (CAS CATO-C4X-113430)
Recommended Standards
- 1-[(3,4-Dichlorophenyl)methyl]-3,5-diiodo-1H-indole-2-carboxylic acid (CAS 860648-96-0)
- (2S,3S,4R)-2-Azido-3,4-bis[(tert-butyldimethylsilyl)oxy]-1-octadecanol (CAS 1256376-21-2)
- 4,4',4''-(2-Bromoethene-1,1,2-triyl)tris(bromobenzene) (CAS 408327-92-4)
- [P(t-Bu)2(n-Bu) Palladacycle Gen. 3] (CAS 2195390-27-1)
- Amidotrizoic Acid Dihydrate EP Impurity E (CAS CATO-C4X-33643)
- Plerixafor Impurity 8 4HCl (CAS 176252-20-3(free base))
- Pemafibrate Impurity 15 (CAS CATO-C4X-290315)
- 2-(4-Chloro-3,5-dimethyl-2-nitrophenoxy)acetamide (CAS 1706458-51-6)
- 1-Boc-4-allyl-4-piperidinecarboxylic Acid (CAS 426842-70-8)
- Acetic acid, 2-[[2-(1,1-dimethylethyl)phenyl]amino]-2-oxo-, methyl ester (CAS 483334-60-7)
- 7-Iodothieno[3,2-c]pyridin-4-ol (CAS 1203579-68-3)
- ethyl 4-chloro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (CAS 50476-72-7)
- 2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine (CAS 1192711-88-8)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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