[5-(difluoromethyl)-3-pyridyl]boronic acid CAS 1382475-69-5
| CAS No. | 1382475-69-5 |
| Molecular Formula | C6H12BF2NO2 |
| Molecular Weight | 178.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
[5-(difluoromethyl)-3-pyridyl]boronic acid (CAS 1382475-69-5) is a high-purity analytical reference standard with the molecular formula C6H12BF2NO2 and a molecular weight of 178.97 g/mol.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, [5-(difluoromethyl)-3-pyridyl]boronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 178.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), [5-(difluoromethyl)-3-pyridyl]boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H12BF2NO2 |
| Molecular Weight | 178.97 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.5 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related difluoromethyl Standards
- 4-(Difluoromethyl)-2-fluoropyridine-3,5-diol (CAS 1805005-33-7)
- 2-(Difluoromethyl)-3,5-dihydroxy-4-fluoropyridine (CAS 1806796-98-4)
- 2-(Difluoromethyl)-3,6-dihydroxy-5-fluoropyridine (CAS 1806912-65-1)
- 2-(Difluoromethyl)-4,5-difluoro-3-methylpyridine (CAS 1803672-95-8)
- 2-(Difluoromethyl)-3,5-difluoroaniline (CAS 1804417-60-4)
- 1-(Difluoromethyl)-2-oxopyrrolidine-3-carboxylic acid (CAS 1586813-24-2)
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Recommended Standards
- 3-Bromofuran-2,4(3H,5H)-dione (CAS 1192-50-3)
- 5-Bromohydantoin (CAS 173904-10-4)
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- (3-Bromo-1,2,4-oxadiazol-5-yl)methanol (CAS 1781503-14-7)
- 2-((2-Methoxyphenyl)amino)-2-oxoethyl 5-bromonicotinate (CAS 721887-61-2)
- 2-({2-[4-(Benzylamino)-4-oxobutanoyl]hydrazino}carbonyl)cyclohexanecarboxylic acid (CAS 914204-20-9)
- 2,2-Dimethyl-1,3-diphenylpropane-1,3-dione (CAS 41169-42-0)
- 3-Butyl-8-(chloromethyl)-7-ethyl-2,3,6,7-tetrahydro-1h-purine-2,6-dione (CAS 848369-63-1)
- N-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenylacetamide (CAS 92447-25-1)
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- Tacrolimus Impurity 36 (CAS 131944-48-4)
- Methyl 2-(2-ethylphenyl)-2-oxoacetate (CAS 143130-97-6)
- 4-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-2-(4-methylphenyl)pyrimidine (CAS 303145-54-2)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
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