2-(Difluoromethyl)-5-oxopyrrolidine-2-carboxylic acid CAS 95755-28-5
| CAS No. | 95755-28-5 |
| Molecular Formula | C6H7F2NO3 |
| Molecular Weight | 179.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-(Difluoromethyl)-5-oxopyrrolidine-2-carboxylic acid (CAS 95755-28-5), a certified reference material (molecular formula C6H7F2NO3, MW 179.12 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Difluoromethyl)-5-oxopyrrolidine-2-carboxylic acid (C6H7F2NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H7F2NO3 |
| Molecular Weight | 179.12 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 1-(Difluoromethyl)-2-oxopyrrolidine-3-carboxylic acid (CAS 1586813-24-2)
- 2-(Difluoromethyl)-4,5-difluoro-3-methylpyridine (CAS 1803672-95-8)
- 2-(Difluoromethyl)-3,5-difluoroaniline (CAS 1804417-60-4)
- 4-(difluoromethyl)-1,3-thiazole-5-carboxylic acid (CAS 2007917-53-3)
- 4-(Difluoromethyl)-2-fluoropyridine-3,5-diol (CAS 1805005-33-7)
- 2-(Difluoromethyl)-3,5-dihydroxy-4-fluoropyridine (CAS 1806796-98-4)
- 2-(Difluoromethyl)-3,6-dihydroxy-5-fluoropyridine (CAS 1806912-65-1)
- 5-(difluoromethyl)pyridine-2-carboxylic acid (CAS 859538-41-3)
Recommended Standards
- (S)-Methyl 4,4-difluoro-5-oxopyrrolidine-2-carboxylate (CAS 333956-61-9)
- 7-Oxo-7,8-dihydro-6H-pyrimido[5,4-β][1,4]oxazine-2-carboxaldehyde (CAS 1003946-48-2)
- (2S,4S)-4-(difluoromethyl)-5-oxopyrrolidine-2-carboxylic acid (CAS 527705-01-7)
- 6-Oxo-6,7-dihydro-5H-pyridazino[3,4-b][1,4]oxazine-3-carbaldehyde (CAS 1003947-30-5)
- (5-Ethylthiophen-2-yl)(pyrrolidin-1-yl)methanone (CAS 774588-59-9)
- N'-(6-(trifluoromethyl)nicotinoyl)benzenesulfonohydrazide (CAS 1092346-06-9)
- 6-(4-Fluorophenyl)-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (CAS 625370-80-1)
- 3-Hydroxy-1,3-di(pyridin-4-yl)prop-2-en-1-one (CAS 129485-46-7)
- 2-Phenyl-4H-spiro[benzo[e][1,4,2]oxazaphosphinine-3,1'-cyclohexane] 2-oxide (CAS 220976-25-0)
- 4-(3-aminopropylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione (CAS 2093388-20-4)
- N-(4-(Azepan-1-yl)but-2-yn-1-yl)benzo[d][1,3]dioxole-5-carboxamide (CAS 1396802-25-7)
- Tert-butyl (4-(ethylamino)phenyl)carbamate (CAS 1111628-40-0)
- (2S,3R,4R,5S,6S)-2-bromo-6-methyltetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 5158-64-5)
- Tetrapeptide-3 (CAS 827306-97-8)
Why CATO?
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