Valsartan Impurity 46 CAS 138402-33-2
| CAS No. | 138402-33-2 |
| Molecular Formula | C14H11BrN4 |
| Molecular Weight | 315.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Valsartan Impurity 46.
As a process- or degradation-related impurity, Valsartan Impurity 46 (CAS 138402-33-2, C14H11BrN4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Valsartan Impurity 46 (C14H11BrN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Valsartan Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11BrN4 |
| Molecular Weight | 315.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Valsartan Standards
- Valsartan Impurity 54 (CAS CATO-C4X-105754)
- Valsartan Impurity 87 (CAS 196707-31-0)
- Valsartan Impurity 100 (CAS CATO-C4X-1057100)
- Valsartan impurity 7 (CAS 914465-68-2)
- Valsartan Impurity 27 (CAS 253678-97-6)
- Valsartan Impurity 109 (CAS 2407652-86-0)
- Valsartan Impurity 20 (CAS CATO-C4X-105720)
- Valsartan Impurity 37 (CAS CATO-C4X-105737)
Recommended Standards
- N-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide (CAS 501693-40-9)
- Diethyl 7-bromoheptylphosphonate (CAS 100462-73-5)
- N-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide (CAS 856898-43-6)
- 1-(2-Bromo-4-fluorobenzyl)piperidine-4-carboxamide (CAS 1061201-04-4)
- Sodium Cromoglicate Impurity 3 (CAS CATO-C4X-20113)
- Olmesartan Impurity 31 (CAS 849206-42-4)
- Ceritinib Impurity 31 (CAS CATO-C4X-104831)
- 1-(1H-Imidazol-2-yl)-N-((tetrahydrofuran-2-yl)methyl)ethanamine (CAS 886505-22-2)
- 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile (CAS 72716-80-4)
- 3-Methyl-3-azabicyclo[3.1.1]heptan-6-amine dihydrochloride (CAS 2089649-12-5)
- 2-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride (CAS 1820740-72-4)
- 1-(2-(2-Fluorophenoxy)phenyl)-1H-tetrazole (CAS 924823-23-4)
- Methyl 6-(4-fluorophenyl)-3-phenylisoxazolo[5,4-b]pyridine-4-carboxylate (CAS 1018125-83-1)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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