Podophyllotoxin impurity 4 CAS 138456-91-4
| CAS No. | 138456-91-4 |
| Molecular Formula | C20H20O8 |
| Molecular Weight | 388.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Podophyllotoxin impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Podophyllotoxin impurity 4 (CAS 138456-91-4), a pharmacopoeial impurity reference standard (molecular formula C20H20O8, MW 388.37 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Podophyllotoxin impurity 4 (C20H20O8) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H20O8 |
| Molecular Weight | 388.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
Related Podophyllotoxin Standards
- Podophyllotoxin Impurity 1 (CAS 1173-42-8)
- Podophyllotoxin impurity 7 (CAS CATO-C4X-24257)
- Podophyllotoxin 4-Deoxy 5-Bromo 6,7-Dihydroxy (CAS 93108-15-7)
- Podophyllotoxin impurity 5 (CAS 1174-97-6)
- Podophyllotoxin Impurity N2 (CAS 42123-27-3)
- Podophyllotoxin EP Impurity C (CAS 477-49-6)
- Podophyllotoxin Impurity 8 (CAS 16481-54-2)
Recommended Standards
- Carbidopa Impurity 28 (CAS CATO-C4X-231028)
- Aranidipine (CAS 86780-90-7)
- Carbidopa Impurity 23 (CAS CATO-C4X-231023)
- Pamoic Acid (CAS 130-85-8)
- Prostaglandin Impurity 32 (CAS CATO-C4X-199632)
- Dabigatran Impurity 2 (CAS 2225986-95-6)
- Dexpanthenol impurity 34 (CAS CATO-C4X-161334)
- Citalopram Impurity 62（Mixture of Enantiomer） (CAS CATO-C4X-110962)
- Methyl 2-(4-chlorophenoxy)-4-fluorobenzoate (CAS 1414959-12-8)
- 5-((3-Chlorophenoxy)methyl)-1,3,4-thiadiazol-2-amine (CAS 1052694-82-2)
- D-Glucuronic acid methyl ester (CAS 52613-19-1)
- 4,5-Dichloro-2-(methylsulfonyl)pyrimidine (CAS 1803805-58-4)
- 1-(2-Bromo-5-chloropyridin-4-yl)ethanone (CAS 1823889-21-9)
- Des-Ile17-Tirzepatide (CAS CATO-CPTD788956)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com