Podophyllotoxin Impurity N2 CAS 42123-27-3
| CAS No. | 42123-27-3 |
| Molecular Formula | C22H18O8 |
| Molecular Weight | 410.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Podophyllotoxin Impurity N2 (CAS 42123-27-3, C22H18O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Podophyllotoxin Impurity N2 (C22H18O8) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures Podophyllotoxin Impurity N2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H18O8 |
| Molecular Weight | 410.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
Related Podophyllotoxin Standards
- Podophyllotoxin EP Impurity C (CAS 477-49-6)
- Podophyllotoxin impurity 5 (CAS 1174-97-6)
- Podophyllotoxin 4-Deoxy 5-Bromo 6,7-Dihydroxy (CAS 93108-15-7)
- Podophyllotoxin impurity 4 (CAS 138456-91-4)
- Podophyllotoxin Impurity 1 (CAS 1173-42-8)
- Podophyllotoxin impurity 7 (CAS CATO-C4X-24257)
- Podophyllotoxin Impurity 8 (CAS 16481-54-2)
Recommended Standards
- Vericiguat impurity 53 (CAS CATO-C4X-289653)
- BKM120 (CAS 1202777-78-3)
- Roxadustat Impurity 28 (CAS CATO-C4X-221328)
- 7-(((4-Methylpyrimidin-2-yl)amino)(4-(trifluoromethyl)phenyl)methyl)quinolin-8-ol (CAS 1351140-16-3)
- Repaglinide Impurity 11 (CAS CATO-C4X-118611)
- Brexpiprazole Impurity 48 (CAS 2059942-13-9)
- Efavirenz Impurity (6-chloro-4-[2-(2-methylcyclopropyl)ethynyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) (CAS 1217623-65-8)
- 3-Bromo-5-methoxypicolinaldehyde (CAS 1211587-04-0)
- 3-Amino-2,4-dichloro-6-fluorobenzoic acid (CAS 1951439-67-0)
- 5-ethynyl-2,2-dimethyl-1,3-dioxane (CAS 102573-86-4)
- 4-[(4-Chlorophenyl)sulfanyl]-N,N-dimethyl-3-nitrobenzamide (CAS 303987-88-4)
- 3,5-Dichloro-N-(4-fluoropiperidin-4-ylmethyl)benzamide (CAS 1038992-15-2)
- 3-Bromo-2-ethylbenzoic acid (CAS 99548-72-8)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com