Candesartan Cilexetil EP Impurity I CAS 139481-69-9
| CAS No. | 139481-69-9 |
| Molecular Formula | C25H22N6O3 |
| Molecular Weight | 454.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 454.48 g/mol gives Candesartan Cilexetil EP Impurity I distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Candesartan Cilexetil EP Impurity I (CAS 139481-69-9) is a certified pharmaceutical impurity reference standard with the molecular formula C25H22N6O3 and a molecular weight of 454.48 g/mol.
The molecular framework of Candesartan Cilexetil EP Impurity I (C25H22N6O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H22N6O3 |
| Molecular Weight | 454.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 6 |
Related Candesartan Standards
- Candesartan-d5 Methyl Ester (CAS 1216502-48-5)
- Candesartan-d5 (CAS 1189650-58-5)
- Candesartan Cilexetil EP Impurity G-d4 (CAS 1346604-70-3)
- Candesartan Cilexetil Impurity 43 (CAS CATO-C4X-123443)
- Candesartan Cilexetil EP Impurity A (CAS 139481-58-6)
- Candesartan N2-Ethyl Impurity (CAS 1246819-02-2)
- Candesartan N1-Ethyl Impurity (CAS 1246817-38-8)
- Candesartan Ethyl Ester Desethyl Analog (CAS 1225044-20-1)
Recommended Standards
- Dabigatran Impurity 43 (CAS 212322-77-5)
- (2R,3R,4S,5S,6R)-2-(acetoxymethyl)-6-(benzylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 74590-46-8)
- N-Nitroso Cinacalcet Impurity 8 (CAS CATO-C4X-105979)
- (2R,3R,4S,5S,6R)-2-(acetoxymethyl)-6-(p-tolylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 211801-79-5)
- Ibrutinib Impurity 84 (CAS CATO-C4X-106484)
- Finerenone Impurity 135 (CAS CATO-C4X-2880135)
- Montelukast Impurity 26 (CAS 120578-03-2)
- Ethyl 3-(4-methoxyphenyl)butanoate (CAS 61292-83-9)
- 1-(2-Amino-1-(4-bromophenyl)ethyl)pyrrolidine-3-carboxylic acid (CAS 886363-99-1)
- Ethyl 3-methyl-3-(p-tolyl)oxirane-2-carboxylate (CAS 74367-97-8)
- 1-(4-Fluorophenyl)-4-methoxy-N-(thiazol-2-yl)-1H-pyrazole-3-carboxamide (CAS 1020455-31-5)
- 5-Chloro-3-(4-fluorophenyl)isoxazole (CAS 137188-20-6)
- 1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-amine (CAS 1201935-36-5)
- Des-Gly34-Tirzepatide (CAS CATO-CPTD788940)
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