Flupirtine Impurity 8 CAS 140-75-0
| CAS No. | 140-75-0 |
| Molecular Formula | C7H8FN |
| Molecular Weight | 125.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Flupirtine Impurity 8 (CAS 140-75-0, C7H8FN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Flupirtine Impurity 8 (C7H8FN) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8FN |
| Molecular Weight | 125.14 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Flupirtine Standards
- Flupirtine Impurity G (CAS 27048-04-0)
- Flupirtine Impurity H (CAS 16013-85-7)
- Flupirtine Impurity C (CAS 21626-43-7)
- Flupirtine-D4 Hydrochloride (CAS 1324717-75-0)
- Acetyl Flupirtine (CAS 95777-69-8)
- Flupirtine Impurity 12 (CAS 91941-04-7)
- Flupirtine Impurity D (CAS 736866-91-4)
- Flupirtine maleate (CAS 75507-68-5)
Recommended Standards
- 2-Fluorobenzylamine (CAS 89-99-6)
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- 3-Fluorobenzylamine (CAS 100-82-3)
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- Baricitinib Impurity 42 (CAS 1146629-77-7)
- Elagolix Impurity 74 (CAS CATO-C4X-206874)
- Lodoxamide lmpurity 11 (CAS 67451-38-1)
- N-benzyl-2-(4-methylpiperazin-1-yl)acetamide (CAS 708994-96-1)
- 3-(3-Methoxy-4-(tosyloxy)phenyl)acrylic acid (CAS 733015-03-7)
- 2-Amino-ethanesulfonic acid(3,4-dimethyl-phenyl)-amide (CAS 954582-82-2)
- 5-(morpholin-4-ylsulfonyl)-2-pyrrolidin-1-ylbenzoic acid (CAS 790271-13-5)
- Ibrutinib Impurity 175 (CAS CATO-C4X-1064175)
- 4-(Iodomethyl)-2-methylthiazole (CAS 105687-33-0)
- Liraglutide Impurity 5 TFA Salt (CAS CATO-C4X-19925)
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