Ibrutinib Impurity 175 CAS CATO-C4X-1064175
| CAS No. | CATO-C4X-1064175 |
| Molecular Formula | C25H27N7O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ibrutinib Impurity 175 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ibrutinib Impurity 175 (CAS CATO-C4X-1064175, C25H27N7O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ibrutinib Impurity 175 (C25H27N7O2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H27N7O2 HCl |
| Molecular Weight | 494.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Ibrutinib Standards
- Ibrutinib Impurity 47 (CAS 1022150-11-3)
- Ibrutinib Impurity 10 (CAS 1022150-12-4)
- Ibrutinib Impurity 80 (CAS 109384-19-2)
- Ibrutinib Impurity 53 (CAS 109831-68-7)
- Ibrutinib Impurity 54 (CAS 1260862-85-8)
- Ibrutinib Impurity 4 (CAS 1288338-95-3)
- Ibrutinib Impurity 3 (CAS 1288338-96-4)
- Ibrutinib Impurity 81 (CAS 143667-36-1)
Recommended Standards
- Baloxavir Impurity 66 (CAS CATO-C4X-210866)
- Hydroxychloroquine Impurity 18 (CAS 860544-46-3)
- Labetalol EP Impurity E HCl (CAS CATO-C4X-246681)
- LCZ-696 Impurity 63 (CAS CATO-C4X-169663)
- 2-(3-Hydroxypyrrolidin-1-yl)nicotinonitrile (CAS 870066-89-0)
- (3S)-azepan-3-amine;dihydrochloride (CAS 334620-16-5)
- Methyl 6-bromo-4-methylpyridazine-3-carboxylate (CAS 1956381-47-7)
- 2-Ethoxytetrahydrofuran (CAS 13436-46-9)
- (R)-3,6-Diaminohexanoic acid (CAS 51703-81-2)
- Tau Peptide (307-321) trifluoroacetate salt (CAS 330456-50-3)
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