Palbociclib Impurity 48 CAS 1415560-29-0
| CAS No. | 1415560-29-0 |
| Molecular Formula | C13H13Br2N3O |
| Molecular Weight | 387.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Palbociclib Impurity 48 (CAS 1415560-29-0, C13H13Br2N3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Palbociclib Impurity 48 (C13H13Br2N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Palbociclib Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13Br2N3O |
| Molecular Weight | 387.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Palbociclib Standards
- Palbociclib Impurity 65 (CAS CATO-C4X-112565)
- Palbociclib Impurity 64 (CAS CATO-C4X-112564)
- Palbociclib Impurity 86 (CAS 2363172-64-7)
- Palbociclib Impurity 192 (CAS CATO-C4X-1125192)
- Palbociclib Impurity N82 (CAS 571190-22-2)
- Palbociclib Impurity 120 (CAS CATO-C4X-1125120)
- Palbociclib Impurity 166 (CAS CATO-C4X-1125166)
- Palbociclib Impurity 63 (CAS CATO-C4X-112563)
Recommended Standards
- 4-Bromo-2-{[(4-bromophenyl)amino]methyl}-6-methoxyphenol (CAS 329059-13-4)
- ((2R,3S,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 6666-38-2)
- 2,4-Dibromo-6-(((2-methoxyphenyl)amino)methyl)phenol (CAS 477871-71-9)
- Tetracosanoyl Chloride (CAS 58576-73-1)
- Lactitol EP Impurity B (CAS 53796-37-5)
- Minocycline Impurity 59 (CAS CATO-C4X-169959)
- Mirogabalin Impurity 177 (CAS CATO-C4X-2924177)
- 4-Methoxy-3-((5-methyl-2-nitrophenoxy)methyl)benzaldehyde (CAS 832737-58-3)
- (3,5-Dibromo-4-butoxyphenyl)methanol (CAS 1697692-87-7)
- 3-Bromo-5-(tetrahydropyran-4-ylmethoxy)-benzoic acid methyl ester (CAS 1948233-82-6)
- Methyl 3-amino-4,6-dibromo-2-methylbenzoate (CAS 119916-05-1)
- Lycoperdic Acid (CAS 69086-72-2)
- 1-(2-(Difluoromethyl)pyridin-3-yl)ethan-1-ol (CAS 1783500-16-2)
- Cholecystokinin Octapeptide free acid (desulfated) (H-2075.0001) (CAS 103974-46-5)
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