Palbociclib Impurity 86 CAS 2363172-64-7
| CAS No. | 2363172-64-7 |
| Molecular Formula | C20H22N6O2 |
| Molecular Weight | 378.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Palbociclib Impurity 86 (CAS 2363172-64-7), a pharmacopoeial impurity reference standard (molecular formula C20H22N6O2, MW 378.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Palbociclib Impurity 86 (C20H22N6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 378.43 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H22N6O2 |
| Molecular Weight | 378.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 6 |
Related Palbociclib Standards
- Palbociclib Impurity 192 (CAS CATO-C4X-1125192)
- Palbociclib Impurity 48 (CAS 1415560-29-0)
- Palbociclib Impurity 65 (CAS CATO-C4X-112565)
- Palbociclib Impurity 166 (CAS CATO-C4X-1125166)
- Palbociclib Impurity 64 (CAS CATO-C4X-112564)
- Palbociclib Impurity 63 (CAS CATO-C4X-112563)
- Palbociclib Impurity 158 (CAS 2639903-34-5)
- Palbociclib Impurity 155 (CAS CATO-C4X-1125155)
Recommended Standards
- N-(2-(Benzo[a]phenazin-5-ylamino)phenyl)acetamide (CAS 61316-66-3)
- Dexamethasone sodium phosphate EP Impurity G (CAS 37927-01-8)
- 4,4-Difluoro-5-((tetrahydro-2H-pyran-2-yl)oxy)pentyl 4-methylbenzenesulfonate (CAS 2226299-15-4)
- Betamethasone Impurity 29 (CAS 37926-75-3)
- N-nitroso Peramivir Impurity 99 (CAS CATO-C4X-183399)
- Butoxybenzene Impurity 14 (CAS 4006-70-6)
- Metoclopramide Impurity 37 (CAS 184151-07-3)
- 3-(2,5,7-Trimethyl-1,3-diazaadamantan-2-yl)propanoic acid (CAS 1171935-10-6)
- Benzyl 7-oxo-3,6-diazabicyclo[3.2.0]heptane-3-carboxylate (CAS 1427378-58-2)
- 5-(azidomethyl)-1,2-oxazole (CAS 497947-78-1)
- 3-(3-aminophenyl)-5-cyclopropyl-5-methylimidazolidine-2,4-dione (CAS 1485279-07-9)
- (4R)-2H-1-Benzopyran-4-amine, 3,4-dihydro-5,8-dimethyl-hydrochloride (1:1) (CAS 2173637-78-8)
- (2S,3S)-3-Mercaptopyrrolidine-2-carboxylic acid (CAS 79068-22-7)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
Why CATO?
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