Adefovir Impurity 8 CAS 1416439-02-5
| CAS No. | 1416439-02-5 |
| Molecular Formula | C19H30N5O7P |
| Molecular Weight | 471.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Adefovir Impurity 8.
Adefovir Impurity 8 (CAS 1416439-02-5) is a certified pharmaceutical impurity reference standard with the molecular formula C19H30N5O7P and a molecular weight of 471.44 g/mol.
Structurally, Adefovir Impurity 8 (C19H30N5O7P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.5, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 471.44 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Adefovir Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H30N5O7P |
| Molecular Weight | 471.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 5 |
Related Adefovir Standards
- Adefovir Dipivoxil (CAS 142340-99-6)
- Adefovir Impurity 28 (CAS CATO-C4X-115228)
- Adefovir Impurity 30 (CAS 365417-53-4)
- Adefovir Impurity 29 (CAS CATO-C4X-115229)
- Adefovir impurity 11 (CAS CATO-C4X-115211)
- Adefovir Impurity 16 (CAS CATO-C4X-115216)
- Adefovir Impurity 4 (CAS 142341-04-6)
- Adefovir impurity 38 (CAS CATO-C4X-115238)
Recommended Standards
- Azilsartan Impurity 42 (CAS CATO-C4X-109642)
- BMS-641988 (CAS 1093276-09-5)
- 2-(5-((3,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)thieno[2,3-b]quinoline (CAS 478260-38-7)
- 2-((4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide (CAS 833439-68-2)
- Levocabastine EP Impurity H (CAS 56326-98-8)
- Lifitegrast Impurity 63 (CAS CATO-C4X-240963)
- Irinotecan Impurity 50 (CAS CATO-C4X-166750)
- 4-Chloro-N-methyl-5-(methylthio)-6-morpholinopyrimidin-2-amine (CAS 83199-51-3)
- 2-[2-(3,5-Dibromo-1H-1,2,4-triazol-1-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione (CAS 1240567-39-8)
- 2-bromo-1-(1-methyl-2-oxabicyclo[2.2.1]heptan-4-yl)ethanone (CAS 2452343-36-9)
- 2,3-O-Carbonyl-α-D-mannopyranose (CAS 76548-27-1)
- 1-(Aminomethyl)-N-methylcyclohexan-1-amine (CAS 90202-99-6)
- 1-Propyl-1h-imidazole-5-carboxylic acid (CAS 676372-32-0)
- 110207-62-0 Acetyl-Cholecystokinin Octapeptide (2-8) (sulfated) MFCD00133565 (CAS 110207-62-0)
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