(+)-Ketoconazole CAS 142128-59-4
| CAS No. | 142128-59-4 |
| Molecular Formula | C26H44Cl2N4O4 |
| Molecular Weight | 547.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (+)-Ketoconazole (CAS 142128-59-4), a certified reference material (molecular formula C26H44Cl2N4O4, MW 547.56 g/mol) for analytical method development and quality control.
Based on its molecular formula C26H44Cl2N4O4, (+)-Ketoconazole contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 547.56 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), (+)-Ketoconazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H44Cl2N4O4 |
| Molecular Weight | 547.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Ketoconazole Standards
- Ketoconazole N-Oxide (and enantiomer) (CAS 254912-65-7)
- Ketoconazole N-Oxide (CAS 1392277-16-5)
- Ketoconazole impurity 33 (CAS CATO-C4X-147233)
- Ketoconazole-d8 (CAS 1217706-96-1)
- Ketoconazole EP Impurity C (and enantiomer) (CAS 83374-59-8)
- Ketoconazole (CAS 65277-42-1)
- Ketoconazole Impurity 26 (CAS CATO-C4X-147226)
- Ketoconazole EP Impurity A (and enantiomer) (CAS 254912-63-5)
Recommended Standards
- (5S,8S,11S)-11-Acetamido-36-hydroxy-8-(4-hydroxybenzyl)-7,10-dioxo-2-oxa-6,9-diaza-1(1,4),3(1,3)-dibenzenacyclododecaphane-5-carboxylic acid (CAS 108890-90-0)
- 3-[(3S)-1-[2-(2-Methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1-(4-nitrophenyl)urea (CAS 1796905-01-5)
- Colchicine EP Impurity D (CAS 477-29-2)
- 4-Amino-1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 177086-37-2)
- (19E)-4-fluoro-17,17-dimethyl-1,5,8,13,15,22,27-heptaazatetracyclo[20.2.2.1¹⁰,¹⁴.0²,⁷]heptacosa-2,4,6,10,12,14(27),19-heptaen-9-one (CAS 2227259-31-4)
- 2-(Thiophen-3-yl)acetamide (CAS 13781-66-3)
- 4-Bromo-3-cyano-2-(hydroxymethyl)benzene-1-sulfonyl chloride (CAS 1804845-71-3)
- 3-(4-fluorobenzoyl)pyridin-2-amine (CAS 869558-51-0)
- 5-(2-Bromophenyl)oxazol-2-amine (CAS 1260795-33-2)
- 2'-Oxo-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-[1,5]naphthyridine]-7'-carboxylic acid (CAS 2765503-66-8)
- 2-(Dimethylamino)butanoic acid hydrochloride (CAS 1394040-12-0)
- (R)-1-[(Pyridin-3-yl)carbonyl]pyrrolidin-3-amine dihydrochloride (CAS 1332765-72-6)
- (3-Bromo-4-methylphenyl)methanamine hydrochloride (CAS 1178904-03-4)
- [D-His1]-Semaglutide (CAS CATO-C4X-2226127)
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