Clopidogrel EP impurity D CAS 1421283-60-4
| CAS No. | 1421283-60-4 |
| Molecular Formula | C24H21Cl2NO4S |
| Molecular Weight | 490.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clopidogrel EP impurity D.
Clopidogrel EP impurity D (CAS 1421283-60-4) is a certified pharmaceutical impurity reference standard with the molecular formula C24H21Cl2NO4S and a molecular weight of 490.40 g/mol.
Clopidogrel EP impurity D (C24H21Cl2NO4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clopidogrel EP impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H21Cl2NO4S |
| Molecular Weight | 490.40 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Clopidogrel Standards
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- Clopidogrel Metabolite II (Mixture of Diastereomers) (CAS 1287430-40-3)
- Clopidogrel Impurity 51 (CAS 1430373-14-0)
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Recommended Standards
- N-(4-chlorophenyl)-2-((4-(2-chlorophenyl)-3-cyano-6-phenylpyridin-2-yl)thio)acetamide (CAS 332128-35-5)
- [(2R,3R,4S,5R,6S)-6-[4-(3,4-dihydroxyphenyl)-7-hydroxy-2-oxochromen-5-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl acetate (CAS 1112383-48-8)
- N-(3-chlorophenyl)-2-((4-(2-chlorophenyl)-3-cyano-6-phenylpyridin-2-yl)thio)acetamide (CAS 332162-79-5)
- 6-O-Acetylastragalin (CAS 118169-27-0)
- Evocalcet impurity 55 (CAS CATO-C4X-248555)
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- 2-(5-Methylbenzofuran-2-yl)benzonitrile (CAS 143381-79-7)
- 3,3-Dimethyl-2-pentanol (CAS 19781-24-9)
- Promethium(III) chloride (CAS 13779-10-7)
- 2-(2-Chlorophenyl)-1,3-thiazole-5-carboxylic acid (CAS 1018520-26-7)
- (4-(Furan-2-yl)phenyl)methanamine (CAS 771573-27-4)
- 1-Ethyl-N-((1-isopropyl-1H-pyrazol-4-yl)methyl)-3-methyl-1H-pyrazol-4-amine hydrochloride (CAS 1856080-56-2)
- Neuropeptide K, porcine (CAS 106441-70-7)
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