Mianserin Impurity 116 CAS 142643-19-4
| CAS No. | 142643-19-4 |
| Molecular Formula | C10H13Cl2N |
| Molecular Weight | 218.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Mianserin Impurity 116 (C10H13Cl2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Mianserin Impurity 116 (CAS 142643-19-4, C10H13Cl2N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13Cl2N |
| Molecular Weight | 218.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Mianserin Standards
- Mianserin impurity 34 (CAS 38869-02-2)
- Mianserin impurity 41 (CAS CATO-C4X-136941)
- Mianserin Impurity 13 (CAS 91247-76-6)
- Mianserin Impurity 68 (CAS CATO-C4X-136968)
- Mianserin Impurity 59 (CAS CATO-C4X-136959)
- Mianserin Impurity 73 (CAS CATO-C4X-136973)
- Mianserin impurity 46 (CAS CATO-C4X-136946)
- Mianserin Impurity 103 (CAS 745757-89-5)
Recommended Standards
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- 6-bromo-7-methyl-1H-indole (CAS 1000343-89-4)
- N,N-Bis(2-chloroethyl)aniline (CAS 553-27-5)
- 1-(1,3-Dioxaindan-5-yl)-2,2,2-trifluoroethan-1-one (CAS 102124-73-2)
- Palbociclib impurity 129 (CAS CATO-C4X-1125129)
- Niraparib Impurity 53 (CAS 1584236-54-3)
- Acotiamide Impurity 37 (CAS 610-90-2)
- Potassium 2-oxoacetate oxoamide (CAS 22742-08-1)
- 4-(Methylthio)pyridin-2(1H)-one (CAS 1018443-25-8)
- Glutathione EP Impurity D (CAS 636-58-8)
- (E)-3-phenyl-2-(3-(trifluoromethyl)styryl)quinazolin-4(3H)-one (CAS 338751-43-2)
- Methyl (Z)-2-chloro-2-(2-(4-chlorophenyl)hydrazono)acetate (CAS 62465-90-1)
- ethyl 1,3-benzothiazole-6-carboxylate (CAS 19989-64-1)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
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