Palbociclib impurity 129 CAS CATO-C4X-1125129
| CAS No. | CATO-C4X-1125129 |
| Molecular Formula | C24H27N9O4 |
| Molecular Weight | 505.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Palbociclib impurity 129 (CAS CATO-C4X-1125129) is a certified pharmaceutical impurity reference standard with the molecular formula C24H27N9O4 and a molecular weight of 505.53 g/mol.
Palbociclib impurity 129 (C24H27N9O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H27N9O4 |
| Molecular Weight | 505.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 9 |
Related Palbociclib Standards
- Palbociclib Impurity 18 (CAS 571189-65-6)
- Palbociclib Impurity 198 (CAS CATO-C4X-1125198)
- Palbociclib Impurity 103 (CAS 2270982-31-3)
- Palbociclib Impurity 79 (CAS CATO-C4X-112579)
- Palbociclib Impurity 85 (CAS CATO-C4X-112585)
- Palbociclib Impurity 136 (CAS CATO-C4X-1125136)
- Palbociclib Impurity 139 (CAS CATO-C4X-1125139)
- Palbociclib Impurity 167 (CAS CATO-C4X-1125167)
Recommended Standards
- Apixaban Impurity 134 (CAS CATO-C4X-1088134)
- Cabozantinib-d4 (CAS 1802168-53-1)
- Pralatrexate Impurity 8 (CAS 374777-77-2)
- Fmoc-D-Asp-ODmb (CAS 200335-63-3)
- Crisaborole impurity 122 (CAS CATO-C4X-2021122)
- Regorafenib Impurity 19 (CAS 2098799-12-1)
- Asparagine EP Impurity C (CAS 98490-54-1)
- Ethyl 2-(4-(hydroxymethyl)phenyl)acetate (CAS 118618-41-0)
- 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-(2-methoxyethoxy)ethyl)propanamide (CAS 1260092-53-2)
- 3-ethyl-N-(piperidin-4-yl)thiophene-2-carboxamide (CAS 1247473-57-9)
- 4-Amino-n-(quinolin-8-yl)benzamide (CAS 1581598-05-1)
- Bis(4-methoxyphenyl)methane (CAS 726-18-1)
- Ramelteon Impurity 50 (CAS CATO-C4X-262250)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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