Niraparib Impurity 53 CAS 1584236-54-3
| CAS No. | 1584236-54-3 |
| Molecular Formula | C16H23NO2 |
| Molecular Weight | 261.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Niraparib Impurity 53 (CAS 1584236-54-3, C16H23NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Niraparib Impurity 53 (C16H23NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 261.36 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Niraparib Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H23NO2 |
| Molecular Weight | 261.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 1 |
Related Niraparib Standards
- Niraparib Impurity 31 (CAS 946076-73-9)
- Niraparib Impurity 49 (CAS 1267209-15-3)
- Niraparib Impurity 60 (CAS CATO-C4X-232960)
- Niraparib Impurity 7 (E-Isomer) (CAS 68109-89-7)
- Niraparib Impurity 7 (Mixture of Isomers) (CAS 93247-79-1)
- Niraparib Impurity 61 (CAS 3112957-16-8)
- Niraparib Impurity 64 (CAS 2820493-80-7)
- Niraparib Impurity 65 (CAS CATO-C4X-232965)
Recommended Standards
- Pentoxyverine Impurity 3 (CAS CATO-C4X-22703)
- Meperidine Impurity 4 (CAS 28018-10-2)
- Bilastine impurity 59 (CAS CATO-C4X-225359)
- 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-(thiophen-2-yl)-1,3-thiazole (CAS 111836-91-0)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
- Lifitegrast Impurity 118 (CAS CATO-C4X-2409118)
- Polmacoxib Impurity 5 (CAS 1778703-66-4)
- Citrusinol (CAS 112516-43-5)
- 7-Azaindole (CAS 271-63-6)
- 4-Hydroxy-7H-pyrrolo[2,3-c]pyridazine-6-carboxylic acid (CAS 1269822-96-9)
- 5-(4,4-Difluoropiperidin-1-yl)nicotinaldehyde (CAS 1707605-04-6)
- Nifursol-desfurfuryliden (CAS 955-07-7)
- (R)-tert-Butyl (5,5-dimethylhex-1-yn-3-yl)carbamate (CAS 2767273-50-5)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
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