Upadacitinib Impurity 18 CAS 1428243-24-6
| CAS No. | 1428243-24-6 |
| Molecular Formula | C15H19NO4 |
| Molecular Weight | 277.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Upadacitinib Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Upadacitinib Impurity 18 (CAS 1428243-24-6) is a certified pharmaceutical impurity reference standard with the molecular formula C15H19NO4 and a molecular weight of 277.32 g/mol.
Upadacitinib Impurity 18 (C15H19NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H19NO4 |
| Molecular Weight | 277.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 126 (CAS CATO-C4X-2405126)
- Upadacitinib Impurity 42 (CAS CATO-C4X-240542)
- Upadacitinib Impurity 43 (CAS 1428243-69-9)
- Upadacitinib Impurity 44 (CAS CATO-C4X-240544)
- Upadacitinib Impurity 71 (CAS 2411540-29-7)
- Upadacitinib Impurity 48 (CAS 1869118-25-1)
- Upadacitinib Impurity 4 (CAS CATO-C4X-24054)
- Upadacitinib Impurity 49 (CAS 1944483-53-7)
Recommended Standards
- Bisacodyl EP Impurity B (CAS 16985-05-0)
- Revefenacin Impurity 39 (CAS 1284980-54-6)
- Nintedanib Impurity 127 (CAS CATO-C4X-1814127)
- Apalutamide impurity 90 (CAS CATO-C4X-274990)
- Dorzolamide Hydrochloride EP Impurity C (CAS CATO-C4X-122816)
- Baloxavir Marboxil Impurity 226 (CAS CATO-C4X-2108226)
- Gonadorelin impurity 5 (CAS CATO-C4X-23545)
- 3,4-Diethyl-2-imino-2H-pyrrol-5-amine (CAS 174396-78-2)
- 4-Acetylfuran-2-sulfonamide (CAS 256373-95-2)
- 3-Carboxy-4-methoxyphenylboronic Acid (CAS 913836-12-1)
- N-[(2E)-2-[(4-Chlorophenyl)methylidene]-5,6-dimethoxy-3-oxo-2,3-dihydro-1H-inden-1-yl]-2,2,2-trifluoroacetamide (CAS 691884-03-4)
- Nilotinib Hydrochloride Monohydrate EP Impurity C (CAS 2458-12-0)
- 2,4,6-Tris(4-carboxyphenoxy)-1,3,5-triazine (CAS 118803-83-1)
- Neuropeptide GE (CAS 134748-04-2)
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