Upadacitinib Impurity 43 CAS 1428243-69-9
| CAS No. | 1428243-69-9 |
| Molecular Formula | C15H19NO4 |
| Molecular Weight | 277.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Upadacitinib Impurity 43 (CAS 1428243-69-9, C15H19NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Upadacitinib Impurity 43 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 277.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H19NO4 |
| Molecular Weight | 277.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 126 (CAS CATO-C4X-2405126)
- Upadacitinib Impurity 18 (CAS 1428243-24-6)
- Upadacitinib Impurity 42 (CAS CATO-C4X-240542)
- Upadacitinib Impurity 44 (CAS CATO-C4X-240544)
- Upadacitinib Impurity 71 (CAS 2411540-29-7)
- Upadacitinib Impurity 48 (CAS 1869118-25-1)
- Upadacitinib Impurity 4 (CAS CATO-C4X-24054)
- Upadacitinib Impurity 49 (CAS 1944483-53-7)
Recommended Standards
- Apalutamide impurity 90 (CAS CATO-C4X-274990)
- Pemafibrate Impurity 40 (CAS CATO-C4X-290340)
- Bisacodyl EP Impurity B (CAS 16985-05-0)
- tert-Butyl 4-(4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate (CAS 138647-52-6)
- Ruxolitinib Impurity 53 (CAS CATO-C4X-205853)
- Neratinib Impurity 5 (CAS CATO-C4X-11345)
- Apremilast Impurity 45 (CAS CATO-C4X-100945)
- 1-(2-(Difluoromethoxy)phenyl)thiourea (CAS 860610-10-2)
- Salbutamol Impurity 80 (CAS 41104-10-3)
- Methyl 4-bromo-2-((4-chlorophenyl)sulfonyl)thiazole-5-carboxylate (CAS 1000575-22-3)
- 5,6-Diphenyl-1,3,3a,4,7,7a-hexahydroisobenzofuran (CAS 823179-46-0)
- (5-bromo-2-propoxyphenyl)methanol (CAS 693823-10-8)
- 2-Acetyl-6,7-dihydrobenzo[b]thiophen-4(5H)-one (CAS 74458-89-2)
- Tirzepatide Impurity 45 (CAS CATO-C4X-324045)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com