Upadacitinib Impurity 49 CAS 1944483-53-7
| CAS No. | 1944483-53-7 |
| Molecular Formula | C13H11N3O2S |
| Molecular Weight | 273.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Upadacitinib Impurity 49 (C13H11N3O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Upadacitinib Impurity 49 (CAS 1944483-53-7, C13H11N3O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Upadacitinib Impurity 49 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H11N3O2S |
| Molecular Weight | 273.31 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 4 (CAS CATO-C4X-24054)
- Upadacitinib Impurity 48 (CAS 1869118-25-1)
- Upadacitinib Impurity 71 (CAS 2411540-29-7)
- Upadacitinib Impurity 126 (CAS CATO-C4X-2405126)
- Upadacitinib Impurity 18 (CAS 1428243-24-6)
- Upadacitinib Impurity 42 (CAS CATO-C4X-240542)
- Upadacitinib Impurity 43 (CAS 1428243-69-9)
- Upadacitinib Impurity 44 (CAS CATO-C4X-240544)
Recommended Standards
- Carbocisteine Impurity 57 (CAS CATO-C4X-201057)
- Fezolinetant Impurity 17 (CAS CATO-C4X-327017)
- Bumetanide Impurity 120 (CAS CATO-C4X-1986120)
- Methyl 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoate (CAS 80036-89-1)
- Losartan EP Impurity C (CAS 114799-13-2)
- Quetiapine Impurity 17 (CAS 2459-05-4)
- Nintedanib Impurity 137 (CAS CATO-C4X-1814137)
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride (CAS 2490665-87-5)
- Dapagliflozin Impurity 131 (CAS CATO-C4X-1138131)
- Methyl 4-methoxypyridine-3-carboxylate (CAS 10177-32-9)
- 2-Amino-3-{[(2-nitrophenyl)methylidene]amino}but-2-enedinitrile (CAS 74900-38-2)
- 2,2-Difluoro-2-(1-hydroxycyclobutyl)acetic acid (CAS 681240-09-5)
- 1-Cyclohexyl-3-(2-hydroxyethyl)urea (CAS 66929-46-2)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com