Tofacitinib Impurity 142 CAS 1431697-80-1

Description

The occurrence of Tofacitinib Impurity 142 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Tofacitinib Impurity 142 (CAS 1431697-80-1) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2 and a molecular weight of 218.34 g/mol.

Tofacitinib Impurity 142 (C14H22N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Tofacitinib Impurity 142 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

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