Sorafenib EP Impurity H CAS 1431697-81-2
| CAS No. | 1431697-81-2 |
| Molecular Formula | C21H16ClF3N4O3 |
| Molecular Weight | 464.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 464.82 g/mol gives Sorafenib EP Impurity H distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Sorafenib EP Impurity H (CAS 1431697-81-2, C21H16ClF3N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sorafenib EP Impurity H (C21H16ClF3N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 464.82 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sorafenib EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H16ClF3N4O3 |
| Molecular Weight | 464.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Sorafenib Standards
- Sorafenib (Base) (CAS 284461-73-0)
- Sorafenib Impurity 40 (CAS 1290546-48-3)
- Sorafenib Impurity 42 (CAS CATO-C4X-112442)
- Sorafenib related compound 26 (CAS 573673-43-5)
- Sorafenib Related Compound 28 (CAS 583840-04-4)
- Sorafenib-d3 (CAS 1130115-44-4)
- Sorafenib Impurity 59 (CAS CATO-C4X-112459)
- Sorafenib Impurity 16 (CAS 1012058-78-4)
Recommended Standards
- ((2R,4S)-4-amino-2-(4-chlorobenzyl)piperidin-1-yl)(3,5-bis(trifluoromethyl)phenyl)methanone (CAS 177707-22-1)
- (2Z)-2-(4-Chlorobenzenesulfonyl)-3-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)prop-2-enenitrile (CAS 1025270-09-0)
- 3-Chloro-N-(3-cyano-4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)benzamide (CAS 477866-92-5)
- Methyl 2-(5-chloro-2-oxo-1-(4-(trifluoromethyl)benzyl)-1,2-dihydropyridine-3-carboxamido)benzoate (CAS 242797-21-3)
- Palbociclib Impurity 41 (CAS CATO-C4X-112541)
- Erythromycin Impurity 13 (CAS 58781-38-7)
- Amorolfine impurity 67 (CAS CATO-C4X-154267)
- 1-[(3-Methoxyphenyl)methyl]-1,4-diazepane (CAS 502142-36-1)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(m-tolyl)methanone (CAS 898757-43-2)
- 4-(4-Methyl-5-(methylthio)-4H-1,2,4-triazol-3-yl)-2-(3-(trifluoromethyl)phenyl)thiazole (CAS 400083-71-8)
- n-((1-Ethyl-1h-imidazol-2-yl)methyl)-1-methyl-1h-pyrazol-4-amine (CAS 1247420-48-9)
- 8-Amino-6-fluoro-5-methylquinoline-2-carboxylic acid (CAS 1420790-46-0)
- 3-(4-Methoxyphenyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidine-7-thiol (CAS 17466-07-8)
- Glucagon receptor antagonist I (CAS 438618-32-7)
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