Acebutolol EP Impurity E CAS 1432053-72-9
| CAS No. | 1432053-72-9 |
| Molecular Formula | C16H26N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 330.85 g/mol gives Acebutolol EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Acebutolol EP Impurity E (CAS 1432053-72-9, C16H26N2O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Acebutolol EP Impurity E (C16H26N2O3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Acebutolol EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H26N2O3 HCl |
| Molecular Weight | 330.85 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Acebutolol Standards
- Acebutolol Impurity 16 (CAS 1180584-47-7)
- Acebutolol-d5 (CAS 1189500-68-2)
- Acebutolol Hydrochloride - Impurity H (Freebase) (CAS 1329613-31-1)
- Acebutolol EP Impurity G (CAS 1330165-98-4)
- Acebutolol EP Impurity B (CAS 22568-64-5)
- Acebutolol Hydrochloride - Impurity E (Freebase) (CAS 27783-53-5)
- Acebutolol EP Impurity J (CAS 28197-36-6)
- Acebutolol Impurity 2 (CAS 28197-46-8)
Recommended Standards
- Apixaban impurity 159 (CAS CATO-C4X-1088159)
- Aripiprazole EP Impurity D (CAS 203395-82-8)
- Ramelteon Impurity 44 (CAS 221530-40-1)
- 1,1'-(Oxybis(4,1-phenylene))bis(2-phenylethan-1-one) (CAS 51930-25-7)
- (5-Amino-2-methoxyphenyl)boronic acid (CAS 948592-70-9)
- 1-(2,2-Diethoxyethyl)-1h-pyrazole (CAS 98881-10-8)
- (E)-(1-(3-ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethylidene)hydrazine (CAS 401464-31-1)
- Ethyl 5-amino-1-(3-fluorophenyl)-3-methyl-1H-pyrazole-4-carboxylate (CAS 1993173-48-0)
- Ethyl 5-(5-bromopyridin-2-yl)-3-methylisoxazole-4-carboxylate (CAS 1311280-10-0)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
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